多模态磁共振成像在帕金森病伴抑郁研究中的应用  

Application of multimodal magnetic resonance imaging in the research on depression in Parkinson disease

作　　者：王惠[1] 马先军[1] 徐剑霞 任静茹 郭志颖(综述) 刘卫国(审校)[3] WANG Hui;MA Xianjun;XU Jianxia(Department of Encephalopathy,Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine,Lianyungang 222004,China)

机构地区：[1]南京中医药大学附属连云港医院脑病科,江苏连云港222004 [2]苏州大学附属独墅湖医院神经内科,江苏苏州215125 [3]南京医科大学附属脑科医院神经内科,江苏南京210029

出　　处：《中风与神经疾病杂志》2024年第11期993-998,共6页Journal of Apoplexy and Nervous Diseases

基　　金：国家重点研发计划重点专项(2017YFC1310302);江苏省科技计划项目重点项目(BE2019611);连云港市科协软课题研究项目(Lkxyb23217)。

摘　　要：抑郁是帕金森病最常见也是最早出现的非运动症状之一,其发生显著增加帕金森病患者、照料者乃至社会的负担。由于临床诊疗对非运动症状的忽视,且抑郁与PD其他症状表征存在交叉,对PD抑郁的识别或治疗均存在严重不足。因此,寻找PD抑郁客观的生物标志物具有重要的研究意义和应用价值。多模态磁共振成像技术的发展为这一目标的实现提供了可能。不同的磁共振成像方式发现帕金森病伴抑郁的大脑损害涉及范围广泛,和原发性抑郁症有相似的病理改变,也存在着其特异性大脑结构和功能的异常。但尚未构建出确切的帕金森病伴抑郁的病理模型,多模态磁共振成像技术在研究帕金森病伴抑郁的病理生理机制,筛查其早期诊断及疗效监测的生物标志物等方面存在着广泛的应用前景。Depression is one of the most common and earliest non-motor symptoms of Parkinson disease(PD)and can significantly increase the burden on PD patients,caregivers,and society.Due to the neglect of non-motor symptoms in clinical diagnosis and treatment and the overlaps between depression and other symptoms of PD,there are serious defi⁃ciencies in the diagnosis or treatment of depression in PD,and therefore,it is of great significance to identify objective bio⁃markers for depression in PD and investigate their application value.The development of multimodal magnetic resonance imaging makes it possible to achieve this goal.Multimodal MRI has revealed a wide range of brain lesions in PD with de⁃pression,with similar pathological changes as primary depression,as well as specific abnormalities in brain structure and function.At present,there is still no exact pathological model for PD with depression,and multimodal MRI has promising application prospects in exploring the pathophysiological mechanisms of PD with depression and identifying the biomarkers for early diagnosis and monitoring.

关 键 词：多模态磁共振成像 帕金森病 抑郁 生物标志物 

分 类 号：R742.5[医药卫生—神经病学与精神病学]