枯草芽胞杆菌在医药及功能性食品等领域的研究现状及应用进展  

Research status and application progress of Bacillus subtilis in the fields of medicine and functional foods

作　　者：李婧 霍毅欣 郭淑元[1] LI Jing;HUO Yixin;GUO Shuyuan(School of Life Science,Beijing Institute of Technology,Beijing 100081,China;Tangshan Research Institute,Beijing Institute of Technology,Tangshan 063611,Hebei,China)

机构地区：[1]北京理工大学生命学院,北京100081 [2]北京理工大学唐山研究院,河北唐山063611

出　　处：《微生物学通报》2024年第11期4327-4348,共22页Microbiology China

基　　金：唐山市科技计划(23130228E);国家自然科学基金(32370095)。

摘　　要：枯草芽胞杆菌(Bacillus subtilis)作为一种广泛应用的优秀微生物平台,在生物医药和食品领域发挥着重要作用,被广泛应用于合成各类酶制剂、化合物、药物和保健品等。借助不断发展的基因工程技术和代谢工程方法,结合完善的基因组序列、遗传工具箱和生物信息学工具,可以更充分地探索和预测枯草芽胞杆菌的潜在应用价值,为相关产业提供指导。然而,在优化代谢途径以提高目的产量、挖掘合成其他物质潜力和开发更高效适配元件方面仍存在挑战。此外,确保枯草芽胞杆菌在医药和食品领域的安全性,以避免不良影响也非常必要。本文总结了枯草芽胞杆菌在生物合成领域(如医药和功能性食品)中的应用,同时探讨了枯草芽胞杆菌作为未来绿色安全微生物平台的应用现状,并对其产品的发展趋势和技术手段等问题进行了讨论。本文为进一步研究枯草芽胞杆菌的应用和经济价值奠定了基础,表明其在绿色和可持续发展方面具有巨大潜力。Bacillus subtilis serves as a widely used elite microbial platform,playing a pivotal role in biomedicine and food industries.It is extensively employed in synthesizing a variety of enzymes,compounds,pharmaceuticals,and health products.The advancing genetic engineering and metabolic engineering approaches,together with comprehensive genomic sequences,genetic toolkits,and bioinformatics tools enable exploring the potential applications of B.subtilis.This exploration offers valuable guidance for related industries.Nonetheless,challenges remain in optimizing metabolic pathways to enhance desired yields,investigating the synthesis potential for other substances,and developing more efficient adapter biobricks.Additionally,ensuring the safety of B.subtilis in biomedicine and food is crucial to prevent adverse effects.This review encapsulates the use of B.subtilis in biosynthesis of medicine and functional foods,discusses the current application status of B.subtilis as a future green and safe microbial platform,and prospects the trends and technical development of its products.This review lays the groundwork for further probing into the application and economic value of B.subtilis,showcasing its immense potential for green and sustainable development.

关 键 词：枯草芽胞杆菌 医药 功能性食品 益生菌 

分 类 号：Q949.9[生物学—植物学]