Forkhead box K1 deficiency alleviates ischemia-reperfusion-induced acute kidney injury  

作　　者：LI Chen 李晨(Dept Nephrol,Renmin Hosp,Wuhan Univ,Wuhan 430060,China)

机构地区：[1]Dept Nephrol,Renmin Hosp,Wuhan Univ,Wuhan 430060,China

出　　处：《China Medical Abstracts(Internal Medicine)》2024年第3期176-177,共2页中国医学文摘（内科学分册英文版）

摘　　要：Objective To investigate the effect and mechanism of forkhead box K1 (FOXK1) in acute kidney injury(AKI),and to provide new ideas and targets for preventing and treating AKI.Methods Three models of AKI were established:30 male specific pathogen free wild type C57BL/6 mice aged 8-10 weeks and weighing 22-24 g were randomly divided into saline group(0.9%normal saline 0.1 ml/10 g,intraperitoneal injection),lipopolysaccharide(LPS) group(LPS solution 10 mg/kg,intraperitoneal injection),cisplatin group (cisplatin solution 20 mg/kg,intraperitoneal injection),ischemia-reperfusion (IR) group,and sham-operated group by the random number table,with 6 mice in each group.

关 键 词：C57BL/6 ISCHEMIA REPERFUSION 

分 类 号：R692[医药卫生—泌尿科学]