Research advances of tetrahedral framework nucleic acid-based systems in biomedicine  

作　　者：Lihang Wang Mary Li Javier Chunshan Luo Tingsheng Lu Shudan Yao Bing Qiu Yun Wang Yunfeng Lin 

机构地区：[1]Department of Spine Surgery,Beijing Jishuitan Hospital Guizhou Hospital,Guiyang 550014,China [2]State Key Laboratory of Oral Diseases,National Center for Stomatology,National Clinical Research Centre for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China [3]Sichuan Provincial Engineering Research Center of Oral Biomaterials,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2024年第11期35-43,共9页中国化学快报（英文版）

基　　金：supported by National Key R&D Program of China(No.2019YFA0110600);National Natural Science Foundation of China(Nos.82370929,81970916);Sichuan Science and Technology Program(No.2022NSFSC0002);Sichuan Province Youth Science and Technology Innovation Team(No.2022JDTD0021);Research and Develop Program,West China Hospital of Stomatology Sichuan University(No.RD03202302);Science and technology support plan project of Guizhou Provincial Department of science and technology(No.Qiankehe support[2022]General264)。

摘　　要：This article reviews the latest research advances of tetrahedral framework nucleic acid(t FNA)-based systems in their fabrication,modification,and the potential applications in biomedicine.TFNA arises from the synthesis of four single-stranded DNA chains.Each chain contains brief sequences that complement those found in the other three,culminating in the creation of a pyramid-shaped nanostructure of approximately 10 nanometers in size.The first generation of t FNA demonstrates inherent compatibility with biological systems and the ability to permeate cell membrane effectively.These attributes translate into remarkable capabilities for regulating various cellular biological processes,fostering tissue regeneration,and modulating immune responses.The subsequent evolution of t FNA introduces enhanced adaptability and a relatively higher degree of biological stability.This advancement encompasses structural modifications,such as the addition of functional domains at the vertices or side arms,integration of low molecular weight pharmaceuticals,and the implementation of diverse strategies aimed at reversing multi-drug resistance in tumor cells or microorganisms.These augmentations empower t FNA-based systems to be utilized in different scenarios,thus broadening their potential applications in various biomedical fields.

关 键 词：DNA nanomaterials Tetrahedral framework nucleic acid Drug delivery ANTIOXIDATION IMMUNOMODULATION Tissue regeneration Antitumor therapy 

分 类 号：R318[医药卫生—生物医学工程]