A natural nano-platform:Advances in drug delivery system with recombinant high-density lipoprotein  

作　　者：Zhilong Xie Guohui Zhang Ya Meng Yefei Tong Jian Deng Honghui Li Qingqing Ma Shisong Han Wenjun Ni 

机构地区：[1]Zhuhai Clinical Medical College of Jinan University(The Department of Urology,Zhuhai People's Hospital),Zhuhai 519050,China [2]Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment,Zhuhai Institute of Translational Medicine,Zhuhai People's Hospital(Zhuhai Clinical Medical College of Jinan University),Zhuhai 519050,China [3]The Second Clinical Medical College,Guangdong Medical University,Dongguan 523808,China [4]Guizhou Aerospace Hospital,Guizhou 563099,China

出　　处：《Chinese Chemical Letters》2024年第11期74-86,共13页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.52273128,82003450);the Natural Science Foundation of Guangdong Province(No.2022A1515220048);the Natural Science Foundation of Guizhou Province(Nos.Guizhou Province-ZK[2022]General 300,Guizhou Province-ZK[2023]General 244);the Xiangshan Talented Scientific Research Foundation of Zhuhai People’s Hospital(No.2023XSYC-01);Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment(No.2021B1212040004)。

摘　　要：Developing natural nano-platforms with high biocompatibility and natural targeting ability represents great significance for drug delivery.High-density lipoprotein(HDL),a natural lipid-protein complex,plays important roles in physiological activities,particularly in reverse cholesterol transport(RCT)and be closely associated with atherosclerotic cardiovascular diseases.Recent studies have demonstrated that HDLs have the potential to serve as ideal drug carriers.Recombinant HDLs(r HDLs)have been used to encapsulate substances such as small interfering RNA(siRNA),drugs,and contrast agents,fully utilizing the biocompatibility and targeting ability of r HDL in the body and providing new strategies for drug delivery and disease treatment.In this review,we discussed in detail the basic principles of HDL as a drug delivery system,the mechanisms of targeted drug delivery,and several methods for preparing HDL nanoparticles.Afterward,we comprehensively reviewed the applications of HDL as a drug carrier in cardiovascular diseases,cancer treatment(such as glioblastoma,breast cancer,hepatocellular carcinoma and urologic cancers)and some other fields.Finally,we reviewed the therapeutic effects and safety of HDL nanoparticles in clinical studies.Through a review and summary of these research advances,we aim to fully understand the potential of HDL as a drug carrier in clinical applications,providing valuable references and guidance for future research and expedites the translational application of HDL as drug carriers.

关 键 词：High-density lipoproteins Drug delivery APOLIPOPROTEIN Targeting mechanisms HDL nanoparticle preparation Cardiovascular disease Cancer treatment 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R943[医药卫生—药剂学]