Metal organic framework modulated nanozymes tailored with their biomedical approaches  

作　　者：Manoj Kumar Sarangi L.D Patel Goutam Rath Sitansu Sekhar Nanda Dong Kee Yi 

机构地区：[1]Department of Pharmaceutics,Amity Institute of Pharmacy,Amity University,Lucknow 201313,India [2]Department of Pharmaceutics,Parul Institute of Pharmacy,Parul University,Vadodara 391760,India [3]Department of Pharmaceutics,School of Pharmaceutical Sciences,Siksha'O'Anusandhan University,Bhubaneswar 751030,India [4]Department of Chemistry,Myongji University,Yongin 03674,Republic of Korea

出　　处：《Chinese Chemical Letters》2024年第11期155-171,共17页中国化学快报（英文版）

摘　　要：Nanozymes are the paradigm for bridging inorganic nanomaterials with biology and environment for taking the spontaneous responsibilities to outplay natural enzymes.Metal-organic frameworks(MOFs) are mesoporous materials of inorganic-organic coordination,bearing ampoules of active/target sites and having the tendency to mimic natural enzymes.Thus MOF-based nanozymes(NZs) could be recognized for their tremendous potential for bio-catalysis.However,MOFs are of four types namely: modified MOFs,pristine MOFs,MOF-derived materials and MOFs comprised of natural enzymes.The MOFs-based NZ modulated via ultrasound,light,and heat revealed diversified applications.This article is concentrated on different methods for the preparation of MOF-based NZ for mimicking the responses of catalases,multifunctional enzymes,oxidases,superoxide dismutase,hydrolases,and peroxidases,progress and challenges of MOFs/MOF-based materials for exploiting their recent and futuristic approaches in biomedical sector.

关 键 词：MOF Nanozyme CATALYSIS BIOMEDICINE THERANOSTICS 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]