A β-lactamase-activatable photosensitizer for the treatment of resistant bacterial infections  

作　　者：Zhipeng Li Qincong Feng Jianliang Shen 

机构地区：[1]National Engineering Research Center of Ophthalmology and Optometry,Eye Hospital,Wenzhou Medical University,Wenzhou 325027,China [2]Zhejiang Engineering Research Center for Tissue Repair Materials,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,China

出　　处：《Chinese Chemical Letters》2024年第11期402-405,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (No.21977081);Zhejiang Provincial Natural Science of Foundation of China (No.LQ21H190006)。

摘　　要：Antibacterial agent of activatable photosensitizer not only has the advantages of traditional photosensitizers,such as good curative effect and low resistance,but also has better selectivity for bacteria and lower toxicity to normal tissues.Limited reports of activatable photosensitizer can be used to treat drugresistant bacteria.In order to meet this challenge,we designed and synthesized an activatable photosensitizer(Ce-OHOA),which can not only selectively identify methicillin-resistant Staphylococcus aureus(MRSA)with high expression ofβ-lactamase by fluorescence imaging,but also kill MRSA with less than10 times the concentration and 10 times the irradiation dose of CySG-2 reported.Ce-OHOA not only combines the dual functions of fluorescence diagnosis and photodynamic therapy,but also selectively acts on bacteria with high expression ofβ-lactamase and has little toxicity to normal cells.We expect that the study of this activating photosensitizer will provide a new solution for antibacterial photodynamic therapy(aPDT)of drug-resistant bacteria.

关 键 词：Activatable photosensitizer MRSA Β-LACTAMASE Fluorescence imaging aPDT 

分 类 号：TQ422[化学工程]