基于两种苯并稠环化合物的核磁共振氢谱研究  

Study on the Proton Nuclear Magnetic Resonance Spectra(1HNMR)Based on Two Types of Benzo-fused Polycyclic Compounds

作　　者：张飞 丁雅丽 张华山 ZHANG Fei;DING Ya-li;Zhang Hua-shan(College of Pharmacy,Qinghai Minzu University,Xining 810007,China;College of Chemistry and Materials Science,Qinghai Minzu University,Xining 810007,China)

机构地区：[1]青海民族大学药学院,青海西宁810007 [2]青海民族大学化学与材料科学学院,青海西宁810007

出　　处：《化学试剂》2024年第12期95-102,共8页Chemical Reagents

基　　金：青海民族大学高层次人才项目(2022GCC08,2021XJG16);青海民族大学大学生创新创业训练计划项目(2024-DCXM-64)。

摘　　要：为了解决部分苯并稠环化合物因在溶剂中不稳定、结构类似不易区分而难以表征的问题,以1-茚酮Z-a、E-a和溶剂中不稳定的异苯并呋喃b为例,变换氘代溶剂、改变浸泡时间、加酸、加碱进行到1HNMR实验研究,结果表明1-茚酮a以Acetone-d 6为溶剂、异苯并呋喃b以DMSO-d 6为溶剂的方法效果最佳。通过研究取代基效应对1-茚酮和异苯并呋喃特征氢化学位移的影响,结果表明获取的1HNMR实验方法可靠、取代基效应对两类化合物特征氢的化学位移影响小。苯并稠环化合物1HNMR的研究丰富了苯并稠环化合物的波谱数据,也对该类化合物结构的表征提供方法。To address the issues with certain benzo-fused polycyclic compounds that are difficult to characterize due to instability in solvents and structural similarity,1HNMR experimental studies were conducted using 1-indanone Z-a,E-a and the solvent-unstable isobenzofuran b as examples by using different deuterated solvents,altering the soaking time,and adding acid and base.The results showed that the optimal method for 1-indanone a was using Acetone-d 6 as the solvent;while for isobenzofuran b,DMSO-d 6 was the best solvent.By studying the effects of substituents on the chemical shifts of characteristic hydrogens in 1-indanone and isobenzofuran,the results demonstrated that the obtained 1HNMR experimental method was reliable and that the substituent effects on the chemical shifts of characteristic hydrogens in these two types of compounds were minimal.The study of 1HNMR of benzo-fused polycyclic compounds enriched the spectroscopic data of these compounds and provided methods for the characterization of their structures.

关 键 词：苯并稠环化合物 1-茚酮 异苯并呋喃 核磁共振氢谱 取代基效应 化学位移 

分 类 号：O656.4[理学—分析化学]