组织蛋白酶在神经系统变性疾病中的研究进展  

Research progress of cathepsins in neurodegenerative diseases

作　　者：姚思彤 徐薇淇 丛树艳[1] YAO Sitong;XU Weiqi;CONG Shuyan(Department of Neurology,Shengjing Hospital of China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院神经内科,沈阳110004

出　　处：《中国医科大学学报》2024年第11期1036-1042,1050,共8页Journal of China Medical University

基　　金：国家自然科学基金(81371271)。

摘　　要：组织蛋白酶是溶酶体中最为丰富的水解酶,负责降解各种底物。目前,越来越多的证据表明,组织蛋白酶在神经系统变性疾病中发挥重要作用。组织蛋白酶通过调节异常蛋白的聚集(α-突触核蛋白、β-淀粉样蛋白、亨廷顿蛋白等)影响疾病的进展,尤其是神经系统中组织蛋白酶B、D、L等的表达及活性异常、基因突变可以导致神经系统变性疾病的发生发展。本文总结了近年来组织蛋白酶在神经系统变性疾病中的研究进展,以期为神经系统变性疾病的早期诊断及治疗提供依据。Cathepsins,the most abundant hydrolases in lysosomes,are responsible for the degradation of various substrates.Increasing evidence suggests that cathepsins play important roles in neurodegenerative diseases.Cathepsins affect the progression of diseases by regulating the aggregation of abnormal proteins(e.g.α-synuclein,amyloidβ-protein,huntington).Abnormal expression levels and activity and gene mutations of cathepsin B,D,and L in the nervous system can lead to the occurrence and development of neurodegenerative diseases.This review summarizes the research progress on cathepsins in neurodegenerative diseases in recent years,with a view to providing a basis for the early diagnosis and treatment of these diseases.

关 键 词：组织蛋白酶 神经系统变性疾病 研究进展 

分 类 号：R741.02[医药卫生—神经病学与精神病学]