化学动力疗法选择性肿瘤治疗模型的数理研究与应用进展  

Mathematical Research and Application Progress of Chemodynamic Therapy for Selective Tumor Treatment Model

作　　者：徐文浩 袁芳 施馨港 李梦[4] XU Wenhao;YUAN Fang;SHI Xingang;LI Meng(Changjiang Institute of Technology,Wuhan 430212,China;Zhushan Traditional Chinese Medicine Hospital,Shiyan 442200,China;Zhushan County People's Hospital,Shiyan 442200,China;College of Environmental Science and Engineering,Donghua University,Shanghai 201620,China)

机构地区：[1]长江工程职业技术学院,湖北武汉430212 [2]竹山县中医医院,湖北十堰442200 [3]竹山县人民医院,湖北十堰442200 [4]东华大学环境科学与工程学院,上海201620

出　　处：《山东化工》2024年第21期126-129,134,共5页Shandong Chemical Industry

摘　　要：化学动力疗法可以产生活性氧物种,因此在肿瘤治疗领域具有较好的前景。Fenton试剂通过纳米药物靶向移送至目标位置,通过将肿瘤微环境中表达的H2O2转化为氧化性的·OH,诱导癌细胞氧化损伤。Fenton反应效率直接影响了治疗效果,越来越多的研究表明,目前的疗效还远远不足以完全根治肿瘤。本文综述了该技术中使用的主要非均相催化剂、主要反应途径及其机理,包括如何从机理上提出策略来强化Fenton反应。本综述为Fenton反应的研究提供了参考,并对未来研究的发展方向提出了一些建议。Chemodynamic therapy has attracted much attention due to its unique reactive oxygen species production mode,which has become an emerging cancer treatment modality.Nanomedicine was designed to deliver Fenton reagent to the tumor site,and based on the Fenton reaction,H 2O 2 expressed in the tumor microenvironment was converted into oxidative·OH,which induces oxidative damage in cancer cells.The efficiency of the Fenton response directly affects the treatment effect,and more and more studies have shown that the current efficacy is far from enough to completely cure the tumor.In this review,we review the main heterogeneous catalysts used in this technology,the main reaction pathways and their mechanisms,including how to propose mechanistic strategies to enhance the Fenton reaction.This review provides a reference for the study of Fenton reaction and puts forward some suggestions for the development direction of future research.

关 键 词：FENTON反应 应用 化学动力疗法 肿瘤治疗 

分 类 号：TQ421[化学工程] R730.5[医药卫生—肿瘤]