高亲和型酪氨酸蛋白激酶类受体和上皮性钙黏连蛋白与鼻腔鼻窦腺样囊性癌病理及预后的关系  

Relationship between high-affinity tyrosine protein kinase-like receptors,epithelial calreticulin and pathology and prognosis of adenoid cystic carcinoma of nasal sinuses

作　　者：黄菊芳 张玉杰[1] 李蓓 单林霞 张璐[1] HUANG Ju-fang;ZHANG Yu-jie;LI Bei;SHAN Lin-xia;ZHANG Lu(Department of Rhinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院鼻科,郑州450000

出　　处：《医药论坛杂志》2024年第20期2203-2207,2212,共6页Journal of Medical Forum

摘　　要：目的分析高亲和型酪氨酸蛋白激酶类受体(tyrosine protein kinase-like receptor,TrkA)、上皮型钙黏蛋白(epithelial calreticulin,E-cadherin)与鼻腔鼻窦腺样囊性癌病理、预后的关系。方法回顾性收集2019年1月—2021年7月郑州大学第一附属医院收治鼻腔鼻窦腺样囊性癌患者样本68例。用免疫组化SP法检测鼻腔鼻窦腺样囊性癌患者组织标本中TrkA、E-cadherin的表达,分析鼻腔鼻窦腺样囊性癌患者的TrkA、E-cadherin表达及与其病理特征的关系。进行随访,用寿命表法计算鼻腔鼻窦腺样囊性癌患者生存状况。用Kaplan-Meir生存曲线分析鼻腔鼻窦腺样囊性癌患者组织中TrkA、E-cadherin的表达与其生存率的关系;用Cox比例风险模型分析影响鼻腔鼻窦腺样囊性癌患者总生存期的危险因素。结果68例鼻腔鼻窦腺样囊性癌患者标本中,TrkA表达阳性率为60例(88.23%),E-cadherin表达阳性率为13例(19.11%)。Ⅲ期~Ⅳ期、实质型、局部有复发者的TrkA高表达占比高于Ⅰ期~Ⅱ期、筛状型/管状型、局部无复发者,差异具有统计学意义(P<0.05);Ⅲ期~Ⅳ期、实质型、局部复发、淋巴结侵犯者的E-cadherin低表达占比高于Ⅰ期~Ⅱ期、筛状型/管状型、局部无复发者,差异具有统计学意义(P<0.05)。经随访了解,18例死亡,1年、2年生存率分别为88.23%、73.52%。经Kaplan-Meir生存曲线得知,TrkA高表达2年生存率为66.67%,低于TrkA低表达组90.00%,差异具有统计学意义(P<0.05);E-cadherin低表达2年生存率为72.13%,低于E-cadherin高表达组的85.71%,差异具有统计学意义(P<0.05)。结论鼻腔鼻窦腺样囊性癌组织中TrkA主要呈高表达,E-cadherin主要呈低表达,两者在鼻腔鼻窦腺样囊性癌发生、发展及预后具有一定作用。进一步探究TrkA和E-cadherin在该癌症中的具体功能和作用机制,对于临床开发新的治疗策略及准确评估患者预后具有重要意义,可为相关治疗提供坚实的理论依据�Objective To analyse the relationship between high-affinity tyrosine protein kinase-like receptor(TrkA),epithelial calreticulin(E-cadherin)and the pathology and prognosis of adenoid cystic carcinoma of the nasal sinuses.Methods A total of 68 patients with adenoid cystic carcinoma of the nasal sinuses admitted to the First Affiliated Hospital of Zhengzhou University from January 2019 to July 2021 were retrospectively collected.The expression of TrkA and E-cadherin in the tissue specimens of patients with adenoid cystic carcinoma of the nasal sinuses was detected by immunohistochemical SP method,and the expression of TrkA and E-cadherin in patients with adenoid cystic carcinoma of the nasal sinuses and the relationship with their pathological features were analysed.Follow-up visits were performed,and the survival status of patients with adenoid cystic carcinoma of the nasal sinuses was calculated using the life table method.The relationship between the expression of TrkA and E-cadherin in the tissues of patients with adenoid cystic carcinoma of the nasal sinuses and their survival was analysed using Kaplan-Meir survival curves;risk factors affecting the overall survival of patients with adenoid cystic carcinoma of the nasal sinuses were analysed using Cox proportional risk models.Results Of the 68 specimens from patients with adenoid cystic carcinoma of the nasal sinuses,60(88.23%)were positive for TrkA expression and 13(19.11%)for E-cadherin expression.The percentage of high expression of TrkA was higher in those with stageⅢ-Ⅳ,parenchymal type,and local recurrence than in those with stageⅠ~Ⅱ,sieve/tubular type,and local no recurrence,and the difference was statistically significant(P<0.05);the percentage of low expression of E-cadherin was higher in those with stageⅢ-Ⅳ,parenchymal type,local recurrence,and lymph node invasion than in those with stageⅠ~Ⅱ,sieve/tubular type,and local no recurrence,and the difference was was statistically significant(P<0.05).On follow-up,18 deaths were known,with 1-ye

关 键 词：高亲和型酪氨酸蛋白激酶类受体 上皮性钙黏连蛋白 鼻腔鼻窦腺样囊性癌 病理特征 预后情况 

分 类 号：R739.62[医药卫生—肿瘤]