康柏西普玻璃体腔注射联合普拉洛芬局部给药治疗糖尿病性白内障术后黄斑水肿疗效观察  

Efficacy of intravitreal injection of conbercept combined with local administrationof pranoprofen on macular edema after diabetic cataract surgery

作　　者：水淼 杨国科 江江 SHUI Miao;YANG Guoke;JIANG Jiang(Department of Ophthalmology,the Third Affiliated Hospital of Anhui Medical University,Hefei 230061,China)

机构地区：[1]安徽医科大学第三附属医院合肥市第一人民医院眼科,安徽合肥230061

出　　处：《陕西医学杂志》2024年第12期1676-1679,共4页Shaanxi Medical Journal

基　　金：安徽省卫生健康委员会科研项目(AHWJ2021B115)。

摘　　要：目的:观察康柏西普玻璃体腔注射联合普拉洛芬局部给药治疗糖尿病性白内障术后黄斑水肿(ME)的疗效。方法:选取糖尿病性白内障术后ME患者106例为研究对象,按照随机数字表法分为pran组(53例)和pran+con组(53例)。pran组在控制血糖等常规治疗基础上给予普拉洛芬滴眼,pran+con组加用康柏西普玻璃体腔注射。比较两组治疗前及治疗后1、3个月眼压,角膜健康情况(角膜内皮细胞密度、六角形细胞比例),最佳矫正视力(BCVA),黄斑中心凹厚度(CMT),治疗3个月后眼底情况,以及不良反应。结果:治疗后1、3个月,两组眼压和CMT随时间降低,且pran+con组低于pran组(均P<0.05);两组BCVA随时间升高,且pran+con组高于pran组(均P<0.05);角膜内皮细胞密度和六角形细胞比例组间、时间及交互比较差异无统计学意义(均P>0.05)。治疗后3个月,pran+con组眼底情况优于pran组(P<0.05)。两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论:康柏西普玻璃体腔注射联合普拉洛芬局部给药治疗糖尿病性白内障术后ME,可有效降低眼压,改善黄斑区厚度和眼底情况,提升视力水平,对角膜内皮细胞无明显毒性作用,具有良好安全性。Objective:To observe the efficacy of intravitreal injection of conbercept combined with local administration of pranoprofen in the treatment of macular edema(ME)after diabetic cataract surgery.Methods:A total of 106 patients with ME after diabetic cataract surgery were selected as the research subjects.According to the random number table method,they were divided into pran group(53 cases)and pran+con group(53 cases).The pran group was given pranoprofen eye drops on the basis of routine treatment such as blood glucose control,while the pran+con group was added with intravitreal injection of conbercept.The intraocular pressure,corneal health status(corneal endothelial cell density,proportion of hexagonal cell),best corrected visual acuity(BCVA)and central macular thickness(CMT)before treatment and after 1,3 months of treatment,and fundus condition after 3 months of treatment,and adverse reactions were compared between two groups.Results:After 1,3 months of treatment,intraocular pressure and CMT in the two groups decreased with time,and those in the pran+con group were lower than those in the pran group(all P<0.05);the BCVA of the two groups increased with time,and the BCVA of the pran+con group was higher than that of the pran group(all P<0.05);the corneal endothelial cell density and proportion of hexagonal cell revealed no statistical differences from the aspects of between group,time-point and interaction(all P<0.05).After 3 months of treatment,the fundus condition of the pran+con group was better than that of the pran group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Intravitreal injection of conbercept combined with local administration of pranoprofen can effectively reduce intraocular pressure,improve macular thickness and fundus condition,and enhance visual acuity in the treatment of ME after diabetic cataract surgery.It has no obvious toxic effect on corneal endothelial cells and has good safety.

关 键 词：黄斑水肿 糖尿病 白内障 康柏西普 普拉洛芬 黄斑厚度 

分 类 号：R774.1[医药卫生—眼科]