胸部大分割放疗在广泛期小细胞肺癌化疗患者中的应用效果  

Application Effect of Thoracic Hypofractionated Radiotherapy in Patients with Extensive-Stage Small Cell Lung Cancer

作　　者：郭慧萍 Guo Huiping(Oncology Department 1,The Second People's Hospital of Datong,Datong 037000,Shanxi Province,China)

机构地区：[1]大同市第二人民医院肿瘤内一科,山西大同037000

出　　处：《中国社区医师》2024年第32期44-46,共3页Chinese Community Doctors

基　　金：大同市重点研发计划项目(编号:2022021)。

摘　　要：目的:探讨胸部大分割放疗在广泛期小细胞肺癌(ES-SCLC)化疗患者中的应用效果。方法:选择2022年12月—2023年10月大同市第二人民医院收治的60例ES-SCLC化疗患者作为研究对象,随机分为观察组和对照组,各30例。对照组采用常规分割放疗,观察组采用大分割放疗。比较两组治疗效果、不良反应发生率、5年生存率、生存期及生活质量。结果:观察组治疗总有效率、5年生存率高于对照组,不良反应总发生率低于对照组,生存期长于对照组(P<0.05)。治疗前,两组躯体功能、社会功能、生理功能、心理功能评分比较,差异无统计学意义(P>0.05);治疗后,两组躯体功能、社会功能、生理功能、心理功能评分高于治疗前,且观察组高于对照组(P<0.05)。结论:胸部大分割放疗在ES-SCLC化疗患者中的应用效果显著,可提高患者5年生存率和生活质量,延长生存期,降低不良反应发生率。Objective:To investigate the application effect of thoracic hypofractionated radiotherapy in patients with extensive-stage small cell lung cancer(ES-SCLC)undergoing chemotherapy.Methods:A total of 60 patients with ES-SCLC undergoing chemotherapy who were admitted to the Second People's Hospital of Datong from December 2022 to October 2023 were selected as the study subjects.They were randomly divided into observation group and control group with 30 cases in each group.The control group received conventional fractionated radiotherapy,and the observation received hypofractionated radiotherapy.The treatment effect,incidence of adverse reactions,5-year survival rate,survival period and quality of life were compared between the two groups.Results:The overall response rate and 5-year survival rate in the observation group were higher than those in the control group,the total incidence of adverse reactions in the observation group was lower than that in the control group,and the survival period in the observation group was longer than that in the control group(P<0.05).Before treatment,there was no significant difference in the scores of physical function,social function,physiological function and psychological function between the two groups(P>0.05).After treatment,the scores of physical function,social function,physiological function and psychological function in the two groups were higher than those before treatment,and the scores in the observation group were higher than those in the control group(P<0.05).Conclusion:The application of thoracic hypofractionated radiotherapy in patients with ES-SCLC undergoing chemotherapy has a significant effect,and can improve the 5-year survival rate and quality of life of patients,prolong the survival period,and reduce the incidence of adverse reactions.

关 键 词：小细胞肺癌 广泛期 化疗 大分割放疗 

分 类 号：R734.2[医药卫生—肿瘤]