代谢重编程介导的肝星状细胞活化在肝纤维化发生机制中的作用  

Role of metabolic reprogramming-mediated hepatic stellate cell activation in the pathogenesis of hepatic fibrosis

作　　者：肖滢 吴治念 鲁洁 王亚东[1] Xiao Ying;Wu Zhinian;Lu Jie;Wang Yadong(Department of Infectious Diseases,the Hebei Medical University Third Hospital,Shijiazhuang050051,China;Department of Laboratory,the Hebei Medical University Third Hospital,Shijiazhuang050051,China)

机构地区：[1]河北医科大学第三医院感染科,石家庄050051 [2]河北医科大学第三医院检验科,石家庄050051

出　　处：《中华肝脏病杂志》2024年第11期1053-1056,共4页Chinese Journal of Hepatology

基　　金：2023年政府资助临床医学优秀人才项目(ZF2023082);河北省自然科学基金项目(H2023206042);河北省青年科技课题(20230701)。

摘　　要：肝星状细胞(HSCs)活化与细胞外基质过度沉积是肝纤维化发生和发展的关键。HSCs活化过程需要大量能量,为满足相应的能量需求,HSCs将通过代谢重编程为肝纤维化形成提供能量支持。该综述重点关注以代谢重编程为特点的代谢组学变化对HSCs活化的影响,概括肝纤维化形成过程中HSCs能量代谢重编程特点,以期为探索肝纤维化发生机制和开发肝纤维化防治策略汇总研究证据。The activation of hepatic stellate cells(HSCs)and excessive deposition of extracellular matrix are the keys to the occurrence and development of liver fibrosis.Metabolic reprogramming supports the activation process of HSCs,which requires substantial energy to meet the corresponding energy requirements for liver fibrosis formation.This review focuses on the effect of metabolomic changes characterized by metabolic reprogramming on HSC activation and summarizes the characteristics of HSC energy metabolism reprogramming during the formation of liver fibrosis,with the aim to summarize research evidence for exploring the mechanism and developing strategies for the prevention and treatment of liver fibrosis.

关 键 词：肝纤维化 肝星状细胞 代谢组学 能量代谢 代谢重编程 

分 类 号：R575.2[医药卫生—消化系统]