血清PSA、PAP、尿肌氨酸联合检测对前列腺癌的诊断价值分析  

Diagnostic value of combined detection of serum PSA, PAP and urinary sarcosine for prostate cancer

作　　者：吴周源 陈从其 陈锦添 李智强 陈闽希 Wu Zhouyuan;Chen Congqi;Chen Jintian;Li Zhiqiang;Chen Minxi(Department of Urology,Ningde Municipal Hospital of Ningde Normal University,Ningde 35210,China;Department of Emergency,Ningde Municipal Hospital of Ningde Normal University,Ningde 352100,China)

机构地区：[1]宁德师范学院附属宁德市医院泌尿外科,宁德352100 [2]宁德师范学院附属宁德市医院急诊科,宁德352100

出　　处：《国际泌尿系统杂志》2024年第6期972-975,共4页International Journal of Urology and Nephrology

摘　　要：目的 探讨尿肌氨酸、前列腺特异性抗原(PSA)、前列腺特异性酸性磷酸酶(PAP)联合检测对前列腺癌(PCa)的诊断价值。方法 选取2016年1月至2018年1月间本院泌尿外科收治并诊断为PCa的60例患者作为PCa组,选取同期60例前列腺增生住院患者作为前列腺增生组,同时选取60例健康者作为正常对照组。采用肌氨酸氧化酶方法对三组研究对象的标本行肌氨酸含量检测,采用放射免疫法测定三组研究对象的PSA、PAP水平,比较各组间的肌氨酸含量及其与血清PSA及病理分级的关系,采用受试者工作特征(ROC)曲线分析PSA、PAP和尿肌氨酸水平联合检测对PCa的诊断效能。结果 PCa组患者的血清PSA、PAP及尿肌氨酸水平较前列腺增生组及正常对照组明显升高,差异均有统计学意义(均P<0.05),而前列腺增生组及正常对照组患者的血清PSA、PAP及尿肌氨酸水平比较,差异均无统计学意义(均P>0.05)。Gleason评分结果显示:Gleason评分越高(分化程度越低、恶性程度越高),血清PSA、尿肌氨酸与PAP水平也越高(均P<0.05)。ROC 曲线分析结果显示,血清PSA、PAP和尿肌氨酸联合检测对PCa具有良好的诊断效能。结论 血清PSA、PAP、尿肌氨酸联合检测能够提高PCa的检测灵敏度以及特异度,可以用于PCa的早期诊断。Objective To investigate the diagnostic value of combined detection of urinary creatinine,prostate-specific antigen(PSA),prostate-specific acid phosphatase(PAP)in patients with prostate cancer(PCa).Methods Sixty patients diagnosed with PCa and admitted to the Department of Urology in our hospital between January 2016 and January 2018 were selected as the PCa group,while sixty hospitalized patients with prostate hyperplasia were chosen as the prostatic hyperplasia group,and another sixty healthy individuals were included as the normal control group.Sarcosine oxidase method was used to detect the content of sarcosine in the samples of the three groups of subjects,and radioimmunoassay was used to determine the levels of PSA and PAP in the three groups of subjects,and the relationship between sarcosine content and serum PSA and pathological grade was compared.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of PSA,PAP and urine sarcosine in PCa.Results Serum PSA,PAP and urine sarcosine levels in prostate cancer group were significantly higher than those in prostate hyperplasia group and normal control group,with statistical significance(all P<0.05),while there was no significant difference between prostate hyperplasia group and normal control group(all P>0.05).The results of the Gleason score demonstrated the following:the higher the Gleason score(the lower the differentiation degree and the higher the malignancy degree),the higher the serum PSA,urine sarcosine and PAP levels(all P<0.05).ROC curve analysis revealed that the combined detection of serum PSA,PAP,and urine sarcosine levels exhibited excellent diagnostic efficacy for PCa.Conclusions The combined detection of serum PSA,PAP,and urine sarcosine can enhance the sensitivity and specificity in detecting PCa,thereby facilitating its early diagnosis.

关 键 词：前列腺肿瘤 前列腺特异抗原 前列腺特异性酸性磷酸酶 肌氨酸 

分 类 号：R737.25[医药卫生—肿瘤]