MRI联合血清PGK-1、DDX5、PSA诊断前列腺癌的临床价值  

Clinical value of MRI combined with serum PGK-1, DDX5 and PSA in the diagnosis of prostate cancer

作　　者：周杨林[1] 张来安[2] 鲁洪[2] 宋强 刘春岭[1] Zhou Yanglin;Zhang Laian;Lu Hong;Song Qiang;Liu Chunling(Department of Interventional Medicine,the People's Hospital of Jiangyou City,Jiangyou 2170,China;Department of Radiology,the People's Hospital of Jiangyou City,Jiangyou 621700,China)

机构地区：[1]江油市人民医院介入医学科,江油621700 [2]江油市人民医院放射科,江油621700

出　　处：《国际泌尿系统杂志》2024年第6期976-980,共5页International Journal of Urology and Nephrology

基　　金：绵阳市卫生健康委员会资助项目(201976)。

摘　　要：目的探究磁共振成像(MRI)联合血清磷酸甘油酸酯激酶-1(PGK-1)、DEADbox RNA解旋酶5(DDX5)、前列腺特异性抗原(PSA)在前列腺癌诊断中的价值。方法选取2020年10月至2022年12月在本院诊治的120例前列腺癌患者作为观察组,同期选取120例前列腺增生患者作为对照组。所有受试者均行MRI检查,并利用酶联免疫吸附法(ELISA)测定血清PGK-1、DDX5水平,采用E601电化学发光分析仪检测血清PSA水平;采用受试者工作特征(ROC)曲线分析血清PGK-1、DDX5、PSA水平对前列腺癌的诊断价值;采用四格表分析MRI联合血清PGK-1、DDX5、PSA检测对前列腺癌的诊断价值。结果与对照组相比,观察组患者的血清PGK-1、DDX5、PSA水平均显著升高(均P<0.05);前列腺癌患者的血清PGK-1、DDX5水平与TNM分期、分化程度、淋巴结转移、Gleason病理分级均有相关性(均P<0.05);PGK-1、DDX5、PSA诊断前列腺癌的ROC曲线下面积(AUC)分别为0.867、0.836、0.812;MRI诊断前列腺癌的灵敏度为81.67%,特异度为82.50%,准确度为82.08%,联合血清PGK-1、DDX5、PSA诊断前列腺癌的灵敏度为94.17%、特异度为81.67%、准确度为87.92%,其诊断效能高于MRI、血清PGK-1、DDX5、PSA单独检测。结论前列腺癌患者的血清PGK-1、DDX5、PSA水平升高,与患者临床病理特征有关,血清PGK-1、DDX5、PSA联合MRI能够提高对前列腺癌的诊断价值。Objective To explore the value of magnetic resonance imaging (MRI) combined with serum phosphoglycerate kinase 1 (PGK-1), DEAD-box RNA helicase 5 (DDX5) and prostate-specific antigen (PSA) in the diagnosis of prostate cancer.Methods The observation group consisted of 120 patients with prostate cancer who received treatment at our hospital from October 2020 to December 2022, while the control group included 120 patients with prostate hyperplasia during the same period. All subjects underwent MRI examination, serum levels of PGK-1, DDX5 and PSA were measured by enzyme linked immunosorbent assay (ELISA). Serum PSA was detected by E601 electrochemiluminescence analyzer. The diagnostic value of serum PGK-1, DDX5 and PSA levels in prostate cancer was analyzed by receiver operating characteristic (ROC) curve. The diagnostic value of MRI combined with serum PGK-1, DDX5 and PSA detection for prostate cancer was analyzed using a four-grid table.Results Compared with the control group, the serum levels of PGK-1, DDX5 and PSA in the observation group were obviously increased (all P<0.05). The levels of serum PGK-1 and DDX5 in patients with prostate cancer were correlated with TNM stage, differentiation, lymph node metastasis, and Gleason pathological grade (all P<0.05), the area under the ROC curve (AUC) of PGK-1, DDX5 and PSA in the diagnosis of prostate cancer was 0.867, 0.836 and 0.812, respectively. The diagnostic efficacy of combined serum PGK-1, DDX5 and PSA was higher than that of MRI, serum PGK-1, DDX5 and PSA alone.Conclusions The serum levels of PGK-1, DDX5 and PSA in patients with prostate cancer increase, they are related to the clinicopathological characteristics of the patients. The combination of the two with MRI can improve the diagnostic value of prostate cancer.

关 键 词：前列腺肿瘤 磁共振成像 磷酸甘油酸酯激酶 DEAD-box解旋酶5 前列腺特异抗原 

分 类 号：R737.25[医药卫生—肿瘤]