血清ING4、sB7-H1表达与膀胱癌根治术后预后的关系  

Relationship between serum ING4 and sB7-H1 expression and prognosis after radical surgery for bladder cancer

作　　者：胡月鹏 刘利峰 王晓鹏 杨丰硕 王浩 Hu Yuepeng;Liu Lifeng;Wang Xiaopeng;Yang Fengsuo;Wang Hao(Department of Urology,Cangzhou People′s Hospital,Cangzhou 061000,China)

机构地区：[1]沧州市人民医院泌尿外科,沧州061000

出　　处：《国际泌尿系统杂志》2024年第6期1019-1023,共5页International Journal of Urology and Nephrology

基　　金：河北省卫生健康委员会2022年度医学科学研究课题计划(20220001)。

摘　　要：目的探讨血清生长抑制因子4(ING4)、可溶性B7-H1(sB7-H1)表达与膀胱癌根治术后预后的关系。方法选取2017年7月至2019年7月在本院行膀胱癌根治术的122例膀胱癌患者作为研究组,另选取同期122例健康体检者作为对照组。采用酶联免疫吸附法(ELISA)检测血清ING4、sB7-H1水平,根据膀胱癌患者ING4、sB7-H1平均值进行分组:ING4<25.21 ng/mL为ING4低表达组(63例),≥25.21 ng/mL为ING4高表达组(59例);sB7-H1<80.47 pg/mL为sB7-H1低表达组(60例),≥80.47 pg/mL为sB7-H1高表达组(62例)。采用Pearson法分析血清ING4与sB7-H1的相关性,采用Kaplan-Meier生存曲线分析ING4、sB7-H1与膀胱癌根治术后预后的关系,根据预后情况将膀胱癌患者分为预后不良组(47例)和预后良好组(75例)。采用Cox回归分析膀胱癌患者根治术后的预后影响因素,绘制受试者工作特征(ROC)曲线分析血清ING4、sB7-H1水平对膀胱癌根治术后预后的预测价值。结果与对照组相比,研究组的血清ING4水平降低,sB7-H1水平升高(均P<0.05)。Pearson相关性分析结果显示,ING4与sB7-H1水平呈负相关(r=-0.701,P<0.05)。血清ING4、sB7-H1表达水平与TNM分期、分化程度有关(均P<0.05)。与预后良好组相比,预后不良组的血清ING4水平降低,sB7-H1水平升高,差异均有统计学意义(均P<0.05)。Kaplan-Meier曲线分析结果显示,ING4高表达组患者的3年生存率为67.80%(40/59),高于ING4低表达组[55.56%(35/63)](χ2=4.914,P<0.05);sB7-H1高表达组患者的3年生存率为53.23%(33/62),低于sB7-H1低表达组[70.00%(42/60)](χ2=10.954,P<0.05)。单因素Cox回归分析结果显示,ING4、sB7-H1是影响膀胱癌根治术后预后的危险因素(均P<0.05);多因素Cox回归分析结果显示,ING4低表达、sB7-H1高表达是影响膀胱癌根治术后预后的危险因素(均P<0.05)。ROC曲线分析结果显示,ING4、sB7-H1联合预测优于各自单独预测(Z=2.632、2.852,均P<0.05)。结论膀胱癌患者血清ING4低表达、sB7-H1�ObjectiveTo investigate the relationship between serum growth inhibitory factor 4(ING4),soluble B7-H1(sB7-H1)expression and prognosis after radical surgery for bladder cancer.MethodsOne hundred and twenty-two bladder cancer patients who underwent radical cystectomy for bladder cancer in our hospital from July 2017 to July 2019 were selected as the study group,and another 122 healthy medical check-ups during the same period were selected as the control group.Serum ING4 and sB7-H1 levels were detected by enzyme-linked immunosorbent assay(ELISA),and the bladder cancer patients were grouped according to the mean number of ING4 and sB7-H1:ING4<25.21 ng/mL was the ING4 low-expression group(63 cases),and≥25.21 ng/mL was the ING4 high expression group(59 cases);sB7-H1<80.47 pg/mL for sB7-H1 low expression group(60 cases),≥80.47 pg/mL for sB7-H1 high expression group(62 cases).The correlation between serum ING4 and sB7-H1 was analysed by Pearson′s method,and the relationship between ING4,sB7-H1 and the prognosis of bladder cancer after radical surgery was analysed by Kaplan-Meier survival curves,and the patients with bladder cancer were classified into the group with poor prognosis and the group with good prognosis according to their prognosis.Cox regression was used to analyse the prognostic influencing factors of bladder cancer patients after radical surgery,and ROC curves were plotted to analyse the prognostic predictive value of serum ING4 and sB7-H1 levels after radical surgery for bladder cancer.ResultsCompared with the control group,the serum ING4 level decreased and sB7-H1 level increased in the study group(all P<0.05).The results of Pearson correlation analysis showed that the levels of ING4 and sB7-H1 were negatively correlated(r=-0.701,P<0.05).Serum ING4 and sB7-H1 expression levels were associated with TNM stage and differentiation degree(all P<0.05).Compared with the group with good prognosis,the serum ING4 level was lower and sB7-H1 level was higher in the group with poor prognosis,and the differences

关 键 词：膀胱肿瘤 生长抑制因子4 可溶性B7-H1 根治手术 

分 类 号：R737.14[医药卫生—肿瘤]