肾癌组织中CBLL1、RBM15蛋白表达与患者临床特征及远期预后的关系  

Relationship between CBLL1,RBM15 protein expression and clinical features,long-term prognosis of patients with renal carcinoma

作　　者：李楠 程海峰 张杰 付晓亮 Li Nan;Cheng Haifeng;Zhang Jie;Fu Xiaoliang(Department of Urology,Xianyang Central Hospital,Xianyang 712000,China)

机构地区：[1]咸阳市中心医院泌尿外科,咸阳712000

出　　处：《国际泌尿系统杂志》2024年第6期1042-1046,共5页International Journal of Urology and Nephrology

基　　金：陕西省科技厅重点研发计划一般项目(S2022-YF-YBSF-0700)。

摘　　要：目的探讨肾癌组织中E3泛素连接酶(CBLL1)、核糖核酸结合蛋白15(RBM15)的蛋白表达与患者临床特征、远期预后的关系。方法选取2018年1月至2020年12月本院收治的102例肾癌患者作为研究对象,将手术过程中取得的癌组织标本纳入肾癌组(102例),将对应的癌旁组织标本纳入癌旁组(102例)。采用免疫组化法检测CBLL1、RBM15在肾癌患者癌组织及癌旁组织中的表达情况;统计分析CBLL1、RBM15表达与肾癌患者临床特征的关系;采用多因素Cox回归分析探讨肾癌患者预后的影响因素。结果肾癌组的CBLL1、RBM15阳性表达率高于癌旁组(均P<0.05)。临床分期为Ⅲ期、有远处转移、有淋巴结转移及肾包膜受侵患者的CBLL1阳性表达率、RBM15阳性表达率均高于临床分期为Ⅰ~Ⅱ期、无远处转移、无淋巴结转移及肾包膜无受侵患者(均P<0.05)。临床分期为Ⅰ~Ⅱ期、无远处转移、无淋巴结转移、肾包膜无受侵、CBLL1阴性、RBM15阴性患者的3年总生存率高于临床分期为Ⅲ期、有远处转移、有淋巴结转移、肾包膜受侵、CBLL1阳性、RBM15阳性患者(均P<0.05)。多因素Cox回归分析结果显示,肾包膜受侵、CBLL1阳性、RBM15阳性是肾癌患者预后的影响因素(均P<0.05)。结论CBLL1、RBM15在肾癌中呈异常表达,与临床分期、淋巴结转移、远处转移、肾包膜受侵等密切相关,有望作为评价肾癌患者预后的分子标志物。ObjectiveTo investigate the relationship between the expression of E3 ubiquitin ligase(CBLL1),ribonucleic acid-binding protein 15(RBM15)and the clinical features,long-term prognosis in renal carcinoma.MethodsA total of 102 patients diagnosed with renal cancer and admitted to our hospital between January 2018 and December 2020 were selected as the subjects for this study.Cancer tissue specimens obtained during surgery were included in the renal cancer group(102 cases),while corresponding paracancerous tissue specimens were included in the paracancer group(102 cases).The expression of CBLL1 and RBM15 in renal carcinoma tissues and adjacent tissues was assessed using the immunohistochemical method.The association between CBLL1 and RBM15 expression and clinical characteristics of patients with renal carcinoma was examined.Multivariate Cox regression analysis was employed to investigate the prognostic factors in patients with renal carcinoma.ResultsThe positive expression rates of CBLL1 and RBM15 in the renal carcinoma group were significantly higher than those in the paracancer group(all P<0.05).The positive expression rates of CBLL1 andRBM15 were significantly higher in patients with clinical stageⅢ,distant metastasis,lymph node metastasis,and renal envelope invasion compared to patients with clinical stageⅠtoⅡ,no distant metastasis,no lymph node metastasis and renal envelope invasion(all P<0.05).The 3-year overall survival rate of patients with clinical stageⅠtoⅡ,no distant metastasis,no lymph node metastasis,no renal capsule invasion,negative CBLL1,and negative RBM15 was significantly higher than that of patients with clinical stageⅢ,distant metastasis,lymph node metastasis,invaded renal capsule,positive CBLL1,and positive RBM15(all P<0.05).Multivariate Cox regression analysis revealed that renal envelope invasion,positive CBLL1,and positive RBM15 were significant prognostic factors for patients with renal carcinoma(all P<0.05).ConclusionsThe aberrant expression of CBLL1 and RBM15 in renal carcinoma is

关 键 词：肾肿瘤 E3泛素连接酶 核糖核酸结合蛋白15 预后 

分 类 号：R737.11[医药卫生—肿瘤]