B族维生素相关一碳代谢与结直肠癌发生发展关系的研究  

Mechanisms and perspectives of B vitamins associated one carbon metabolism on colorectal cancer risk

作　　者：马妍慧[1] 沈立松[1] 郑英霞[1] Ma Yanhui;Shen Lisong;Zheng Yingxia(Department of Clinical Laboratory,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai200092,China)

机构地区：[1]上海交通大学医学院附属新华医院检验科,上海200092

出　　处：《中华预防医学杂志》2024年第11期1739-1751,共13页Chinese Journal of Preventive Medicine

基　　金：国家自然基金面上项目(82071753);上海卫生健康委员会医苑新星杰出青年人才计划(20224Z0025)。

摘　　要：结直肠癌作为一种常见的消化道恶性肿瘤,在全世界范围内严重威胁着人类的健康。B族维生素(叶酸、维生素B2、维生素B6和维生素B12)在代谢过程中能介导转移含一个碳原子的基团,参与生物一碳代谢,包括蛋白质、脂质、核酸和其他辅因子等合成。一碳代谢与其他营养素的代谢形成复杂通路,B族维生素在其中起到原料或辅酶的作用,影响各类中间产物的生成,作为重要营养元素不同程度地参与结直肠癌的发生发展。同时,一碳代谢在表观遗传学、核苷酸合成、氧化还原稳态与肠道菌群相互作用等多方面共同影响肿瘤细胞命运。鉴于这些作用,理解和监测B族维生素水平及其代谢途径对于结直肠癌的预防和管理至关重要。这不仅有助于降低与肿瘤相关的死亡率,还为结直肠癌形成和发展机制研究及潜在治疗策略开辟了新途径。Colorectal cancer(CRC)represents a significant global health challenge as a common malignancy of the digestive tract.The involvement of B vitamins—specifically folic acid(B9),riboflavin(B2),pyridoxine(B6),and cobalamin(B12)—is crucial in metabolic processes by mediating the transfer of one-carbon(1C)units,which plays a fundamental role in cellular functions and tumor growth.1C metabolism is involved in synthesis of proteins,lipids,nucleic acids,and other cofactors.1C metabolism,intertwined with the metabolism of other nutrients,forms complex pathways where B vitamins act as precursors or coenzymes,influencing the production of various intermediates.These vitamins,as essential nutrients,are implicated to varying the pathogenesis and progression of colorectal cancer such as epigenetics.Furthermore,1C metabolism affects tumor cell fate through multiple aspects including nucleotide synthesis,redox homeostasis,and the interaction with gut microbiota.Given these roles,understanding and monitoring B vitamin levels and their metabolic pathways are essential for colorectal cancer prevention and management.This approach not only helps in reducing tumor-related mortality but also opens new avenues for research into CRC mechanisms and potential therapeutic strategies.

关 键 词：结直肠癌 一碳代谢 叶酸 维生素B2 维生素B6 维生素B12 

分 类 号：R735.34[医药卫生—肿瘤]