千屈菜中2个具有抗氧化活性的新酚苷类化合物  

Two new phenolic glucosides with antioxidant activity from Lythrum salicaria

作　　者：王越 杜金风 陈惠苹 徐雪峰 张绪元 WANG Yue;DU Jin-feng;CHEN Hui-ping;XU Xue-feng;ZHANG Xu-yuan(College of Chemistry and Materials Engineering,Hainan Vocational University of Science and Technology,Haikou 571126,China)

机构地区：[1]海南科技职业大学化学与材料工程学院,海南海口571126

出　　处：《中国中药杂志》2024年第21期5914-5918,共5页China Journal of Chinese Materia Medica

基　　金：海南科技职业大学科研启动项目。

摘　　要：综合运用现代色谱分离技术对千屈菜Lythrum salicaria地上部分中具有抗氧化活性的成分进行了系统的分离纯化,采用1D/2D NMR、旋光以及高分辨质谱对纯化的单体化合物进行结构鉴定,共分离鉴定了6个化合物,分别为6′-(对甲氧基苯基)没食子酸-7-O-β-D-葡萄糖苷(1)、6′-乙基对羟基苯乙醇-β-D-葡萄糖苷(2)、3,4,5-三甲氧基苯酚-β-D-葡萄糖苷(3)、3,4,5-三甲氧基苯酚-1-O-β-呋喃芹糖(1″→6′)-β-葡萄糖苷(4)、苯甲醇-O-α-L-阿拉伯糖(1→6)-β-D-葡萄糖苷(5)、6′-乙酰基乙醇-β-D-葡萄糖苷(6)。其中化合物1和2为新的酚苷类化合物,化合物3~6均为首次从千屈菜属植物中分离得到。对鉴定的6个糖苷类化合物进行了抗氧化活性测试,结果表明化合物1具有显著的抗氧化活性,其IC_(50)为0.16 mmol·L^(-1),强于阳性对照水溶性维生素E(IC_(50)为0.24 mmol·L^(-1))。Chromatographic techniques were employed to separate and purify the active components with antioxidant activity from the aboveground part of Lythrum salicaria.The data of 1D/2D NMR,optical rotation,and high-resolution mass spectrometry were used to identify the purified compounds.Six phenolic glucosides were identified,including 6′-(p-methoxyphenyl)gallate-7-O-β-D-glucopyranoside(1),6′-ethyl-p-hydroxyphenylethanol-β-D-glucopyranoside(2),3,4,5-trimethoxyphenol-β-D-glucopyranoside(3),3,4,5-trimethoxyphenyl 1-O-β-apiofuranosyl(1″→6′)-β-glucopyranoside(4),benzylalcohol O-α-L-arabinopyranosyl(1→6)-β-D-glucopyranoside(5),and 6′-acetylethanol-β-D-glucopyranoside(6).Compounds 1 and 2 were novel phenolic glucosides,and compounds 3-6 were isolated from Lythrum for the first time.Furthermore,the antioxidant activities of compounds 1-6 were evaluated.Compound 1 showed potent antioxidant activity,with the half maximal inhibitory concentration(IC_(50))of 0.16 mmol·L^(-1),which was stronger than that of the positive control trolox with the IC_(50)of 0.24 mmol·L^(-1).

关 键 词：千屈菜 酚苷 糖苷 抗氧化活性 

分 类 号：R284.1[医药卫生—中药学]