阿加曲班注射液联合注射用单唾液酸四己糖神经节苷脂钠治疗急性脑梗死的临床效果  

Clinical efficacy of combined argatroban injection and monosialotetrahexosylganglioside sodium injection in the treatment of acute cerebral infarction

作　　者：陈翩翩[1] 高俊杰[1] 陈少群 CHEN Pianpian;GAO Junjie;CHEN Shaoqun(Department 2 of Neurology,Zhanjiang Central People′s Hospital of Zhanjiang,Guangdong Province,Zhanjiang 524000,China)

机构地区：[1]湛江中心人民医院神经内二科,广东省湛江市524000

出　　处：《临床合理用药杂志》2024年第35期15-17,23,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：湛江市科技计划项目(2021B01104)。

摘　　要：目的观察阿加曲班注射液联合注射用单唾液酸四己糖神经节苷脂钠治疗急性脑梗死的临床效果。方法选取2021年5月—2023年4月湛江中心人民医院收治的急性脑梗死患者60例,以随机数字表法分为观察组和对照组,各30例。2组均予常规治疗,在此基础上,对照组予注射用单唾液酸四己糖神经节苷脂钠治疗,观察组在对照组基础上予阿加曲班注射液治疗,2组均治疗2周后比较治疗效果,治疗前后神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]、神经功能因子[神经生长因子(NGF)、生长相关蛋白-43(GAP-43)及脑源性神经营养因子(BDNF)]、脑血流动力学指标[脑平均血流量(Qmean)、平均血流速度(Vmean)、外周阻力(Rv)]以及凝血功能指标[D-二聚体(D-D)、抗凝血酶Ⅲ(AT-Ⅲ)、纤维蛋白原(Fib)]。结果观察组患者治疗总有效率为90.00%,高于对照组的63.33%(χ2=5.963,P=0.015)。治疗2周后,2组NIHSS评分与D-D、Fib水平均较治疗前降低,NGF、GAP-43、BDNF水平、AT-Ⅲ上升,Qmean、Vmean较治疗前增加,Rv减小,且观察组改善程度大于对照组(P<0.05或P<0.01)。结论阿加曲班注射液联合注射用单唾液酸四己糖神经节苷脂钠治疗急性缺血性脑梗死的临床效果肯定,可对神经功能的恢复起到保护和支持作用。Objective To investigate the clinical efficacy of combined argatroban injection and monosialotetrahexosylganglioside sodium injection in the treatment of acute cerebral infarction.Methods A total of 60 patients with acute cerebral infarction admitted to Central People′s Hospital of Zhanjiang from May 2021 to April 2023 were randomly divided into observation group and control group(30 cases in each group)using a random number table.Both groups received routine treatment.On this basis,the control group received monosialotetrahexosylganglioside sodium for injection treatment,while the observation group received argatroban injection treatment in addition to the control group treatment.Both groups were treated for 2 weeks,and then the therapeutic effects were compared.The neurological function(NIHSS score),neurotrophic factors(NGF,GAP-43,BDNF),cerebral hemodynamic parameters(Qmean,Vmean,Rv),and coagulation function indicators(D-D,AT-Ⅲ,Fib)before and after treatment were compared.Results Compared with the control group,the observation group exhibited a significantly higher overall effective rate of treatment(90.00%vs.63.33%,χ2=5.963,P=0.015).After a 2-week treatment period,both groups demonstrated reductions in NIHSS scores and D-D and Fib levels,as well as increases in NGF,GAP-43,BDNF levels,AT-Ⅲ,Qmean,and Vmean,with a decrease in Rv.The improvement in these parameters was more pronounced in the observation group(P<0.05 or P<0.01).Conclusion The combination therapy of argatroban injection and monosialotetrahexosylganglioside sodium injection has demonstrated a positive clinical effect in treating acute cerebral infarction,and it can effectively protect and promote neurological function recovery.

关 键 词：急性脑梗死 阿加曲班 糖神经节苷脂 神经功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]