生物活性玻璃促进成牙本质方向分化的研究进展  

Research progress of bioactive glass promoting odontoblast differentiation

作　　者：夏倩颖 崔彩云 荣丽[1] XIA Qianying;CUI Caiyun;RONG Li(Department of Oral Medicine,Binzhou Medical University Hospital,Shandong,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院口腔内科,山东滨州256600

出　　处：《中国医药科学》2024年第21期36-39,共4页China Medicine And Pharmacy

基　　金：山东省自然科学基金面上项目(ZR2023MH039)。

摘　　要：生物活性玻璃(BG)因其成骨、成血管作用在骨再生和牙周组织再生等领域广泛应用。近年来发现BG可以促进人牙髓干细胞(hDPSCs)或其他相关细胞朝着形成牙本质的方向发展,并能促进牙髓-牙本质复合体的形成。这对于牙髓疾病、根尖周病变等疾病的治疗具有重要意义。BG溶解释放出钙离子、硅离子等特定离子,从而促进牙体硬组织再生;BG溶解后通过离子交换形成碱性微环境,从而发挥抑菌作用;BG通过促进细胞间相互交流,从而增强细胞间联系。这些因素对促进牙源性细胞的成牙本质方向分化具有积极的意义。本文通过回顾和探究BG促进牙源性细胞成牙本质方向分化的作用及其机制,以期为牙髓疾病和根尖周疾病治疗提供研究基础。Bioactive glass(BG)is widely used in the fields of bone regeneration and periodontal tissue regeneration due to its osteogenic and angiogenic effects.In recent years,it has been found that BG can promote the development of human dental pulp stem cells(hDPSCs)or other related cells towards the formation of dentin,and can also promote the formation of dental pulp-dentin complexes.This is of great significance for the treatment of diseases such as pulp disease and periapical lesions.BG dissolution releases specific ions such as calcium and silicon,thereby promoting the regeneration of dental hard tissue.BG dissolves and forms an alkaline microenvironment through ion exchange,thereby exerting antibacterial effects.BG enhances intercellular communication by promoting intercellular communication.These factors have positive significance in promoting the differentiation of odontogenic cells into dentin.This paper reviews and explores the role and mechanism of BG in promoting the differentiation of odontogenic cells into dentin,in order to provide a research basis for the treatment of pulp and periapical diseases.

关 键 词：生物活性玻璃 成牙本质方向分化 牙源性细胞 牙髓-牙本质复合体 机制 

分 类 号：R781[医药卫生—口腔医学]