丁螺环酮对精神分裂症患者认知功能影响的meta分析  

Meta analysis of the effect of buspirone on cognitive function in patients with schizophrenia

作　　者：梁妤静 阳瑞林 杜启峰 陈锋 LIANG Yujing;YANG Ruilin;DU Qifeng;CHEN Feng(Chronic Mental Disorders Department,the Third People’s Hospital of Zhongshan,Guangdong,Zhongshan 528400,China)

机构地区：[1]中山市第三人民医院慢性精神障碍科,广东中山528400

出　　处：《中国医药科学》2024年第21期110-113,138,共5页China Medicine And Pharmacy

基　　金：中山市医学科研项目(2021J288)。

摘　　要：目的运用meta分析法评价丁螺环酮对精神分裂症患者认知功能的影响。方法利用计算机对中国知网、万方、维普、PubMed等数据库检索采集丁螺环酮治疗精神分裂症的随机对照试验(RCTs),时间截至为2024年1月,按照既定纳入和排除标准逐一筛选,对符合的RCTs进行方法学质量评价,运用RevMan 5.3软件进行数据分析。结果共纳入9个RCTs,累计患者895例。meta分析结果显示,丁螺环酮辅助治疗精神分裂症的疗效明显优于对照组,差异有统计学意义[OR=6.07,95%CI(3.53,10.45),Z=6.52,P<0.00001];治疗组认知功能评分高于对照组,差异有统计学意义[MD=3.22,95%CI(2.75,3.69),Z=13.49,P<0.00001];两组不良反应发生率比较,差异无统计学意义[OR=1.12,95%CI(0.66,1.91),Z=0.42,P=0.67]。结论丁螺环酮辅助治疗精神分裂症可有效缓解临床症状,提高认知功能。Objective To evaluate the effect of buspirone on cognitive function in patients with schizophrenia using meta-analysis.Methods China CNKI,Wanfang,VIP and Pubmed databases were searched by computer,and randomized controlled trials(RCTs)of buspirone in the treatment of schizophrenia were collected.The time was up to January 2024,and the eligible RCTs were screened one by one according to the established inclusion and exclusion criteria,and the methodological quality was evaluated.The data were analyzed by RevMan 5.3 software.Results A total of 9 RCTs were included,with a cumulative total of 895 patients.The meta-analysis results showed that the efficacy of buspirone as an adjuvant therapy for schizophrenia was significantly better than that of the control group,and the difference was statistically significant(OR=6.07,95%CI[3.53,10.45],Z=6.52,P<0.00001).The cognitive function score of the treatment group was higher than that of the control group,and the difference was statistically significant(MD=3.22,95%CI[2.75,3.69],Z=13.49,P<0.00001).There was no statistically significant difference in the incidence of adverse effect between the two groups(OR=1.12,95%CI[0.66,1.91],Z=0.42,P=0.67).Conclusion Adjuvant treatment with buspirone can effectively alleviate clinical symptoms and improve cognitive function in schizophrenia.

关 键 词：精神分裂症 丁螺环酮 临床疗效 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]