血清胃蛋白酶原、胃泌素-17在鸡皮样胃炎中的应用研究  

Application of Serum Pepsinogen,Gastrin-17 in Chicken Skin Gastritis

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作  者:张荣山[1] 谢宁生[2] 李志平 ZHANG Rongshan;XIE Ningsheng;LI Zhiping(Department of Clinical Laboratory,Ganzhou People's Hospital,Ganzhou 341000,China;不详)

机构地区:[1]赣州市人民医院检验科,江西赣州341000 [2]赣州市人民医院消化内科,江西赣州341000

出  处:《中国医学创新》2024年第30期106-109,共4页Medical Innovation of China

基  金:赣州市指导性科技计划项目(GZ2023ZSF002)。

摘  要:目的:探究血清胃蛋白酶原、胃泌素-17(G-17)在鸡皮样胃炎中的应用价值。方法:选取2023年1—10月赣州市人民医院收治的80例内镜下发现鸡皮样胃炎及^(14)C呼气试验阳性患者作为观察组,另选择本院同期80例体检健康者作为对照组。比较两组胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、G-17的水平。观察组进行抗鸡皮样胃炎幽门螺杆菌(Hp)感染治疗,评估观察组治疗后预后情况,根据^(14)C呼气试验结果分为预后良好组和预后不良组,分析两组的血清胃蛋白酶原及G-17。分析血清胃蛋白酶原、G-17联合检测对鸡皮样胃炎的诊断价值。结果:观察组PGⅠ、PGR、G-17表达值均低于对照组(P<0.05),两组PGⅡ表达水平比较,差异无统计学意义(P>0.05)。治疗后,预后良好组PGⅠ、PGR、G-17水平明显高于预后不良组(P<0.05)。PGⅠ、PGR、G-17联合检测的敏感度和特异度均高于PGⅠ、PGR、G-17单项检测。结论:血清胃蛋白酶原、G-17、^(14)C呼气试验检测在鸡皮样胃炎的临床诊断中都具有一定的价值,通过检测胃蛋白酶原、G-17可评估患者的临床治疗效果,且G-17和胃蛋白酶原联合检测对鸡皮样胃炎具有较高的诊断价值。Objective:To explore the application value of serum pepsinogen,gastrin-17(G-17)in chicken skin gastritis.Method:A total of 80 cases of endoscopic chicken skin gastritis and^(14)C breath test positive patients admitted to Ganzhou People's Hospital from January to October 2023 were selected as the observation group,and another 80 healthy patients in our hospital during the same period were selected as the control group.The levels of pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ)and G-17 were compared between the two groups.The observation group was treated with Helicobacter pylori(Hp)infection against chicken skin gastritis.To evaluate the prognosis of the observation group after treatment,the observation group was divided into good prognosis group(n=68)and poor prognosis group(n=12)according to the^(14)C breath test results,and the serum pepsinogen and G-17 of the two groups were analyzed.The diagnostic value of serum pepsinogen and G-17 combined detection in chicken skin gastritis was analyzed.Result:The expression levels of PGⅠ,PGR and G-17 in the observation group were lower than those in the control group(P<0.05),but there was no significant difference in the expression levels of PGⅡbetween the two groups(P>0.05).After treatment,the levels of PGⅠ,PGR and G-17 in good prognosis group were significantly higher than those in poor prognosis group(P<0.05).The sensitivity and specificity of PGⅠ,PGR and G-17 combined detection were higher than those of PGⅠ,PGR and G-17 single detection.Conclusion:Serum pepsinogen,G-17 and^(14)C breath test are of certain value in the clinical diagnosis of chicken skin gastritis,and the clinical therapeutic effect of patients can be evaluated by the detection of pepsinogen and G-17,and the combined detection of G-17 and pepsinogen has a high diagnostic value for chicken skin gastritis.

关 键 词:胃蛋白酶原 ^(14)C呼气试验 鸡皮样胃炎 胃泌素-17 抗感染治疗 

分 类 号:R573.3[医药卫生—消化系统]

 

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