鲁拉西酮联合低剂量奥氮平治疗女性精神分裂症的疗效及对患者催乳素水平的影响  

Efficacy of lurasidone combined with low-dose olanzapine in the treatment of female schizophrenia and its impact on prolactin levels in patients

作　　者：李丹丹 乔云云 罗红霞 LI Dan-dan;QIAO Yun-yun;LUO Hong-xia(Department of Psychiatry,Zhumadian Second People's Hospital,Zhumadian 463000,Henan,CHINA;Department of Child and Youth Psychology,Zhumadian Second People's Hospital,Zhumadian 463000,Henan,CHINA)

机构地区：[1]驻马店市第二人民医院精神六科,河南驻马店463000 [2]驻马店市第二人民医院儿少心理科,河南驻马店463000

出　　处：《海南医学》2024年第22期3241-3244,共4页Hainan Medical Journal

基　　金：中国生命关怀协会生命质量照护研究项目(编号:HL20210112)。

摘　　要：目的 研究鲁拉西酮联合低剂量奥氮平治疗女性精神分裂症的疗效及对患者催乳素水平的影响。方法 选取2022年9月至2024年2月驻马店市第二人民医院收治的106例女性精神分裂症患者作为研究对象,按随机数表法分为研究组和对照组各53例,对照组患者采用低剂量奥氮平治疗,研究组患者采用低剂量奥氮平联合鲁拉西酮治疗,两组患者均治疗8周。治疗8周后,比较两组患者的阳性症状量表(SAPS)和阴性症状量表(SANS)评分、糖脂代谢指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、高密度脂蛋白胆固醇(HDL)]、催乳素和蒙特利尔认知评估量表(MoCA)评分;同时比较两组患者治疗期间的不良反应发生率。结果 治疗前,两组患者的SAPS、SANS评分比较差异均无统计学意义(P>0.05);治疗8周后,两组患者的SAPS、SANS评分较治疗前均降低,且研究组患者的SAPS、SANS评分分别为(45.26±2.80)分、(46.52±9.08)分,明显低于对照组的(59.20±3.72)分,(55.28±12.49)分,差异均有统计学意义(P<0.05)。治疗前,两组患者的TC、TG、LDL、FBG、HbA1c、HDL和催乳素水平比较差异均无统计学意义(P>0.05);治疗8周后,两组患者的TC、TG、LDL、FBG、Hb A1c及催乳素水平均升高,HDL降低,差异均有统计学意义(P<0.05),但两组患者治疗后的上述指标比较差异均无统计学意义(P>0.05)。治疗8周后,两组患者的Mo CA评分均高于治疗前,且研究组患者的Mo CA评分为(27.86±2.09)分,明显高于对照组的(24.23±2.56)分,差异均有统计学意义(P<0.05)。研究组患者的不良反应总发生率为5.66%,略低于对照组的7.55%,但差异无统计学意义(P>0.05)。结论 低剂量奥氮平联合鲁拉西酮治疗女性精神分裂症较单用低剂量奥氮平疗效好,可改善患者的认知功能,且对糖脂代谢及催乳素水平无明显影响,安全可靠。Objective To study the efficacy of lurasidone combined with low-dose olanzapine in the treatment of female schizophrenia and its impact on prolactin levels in patients.Methods A total of 106 patients with female schizophrenia in Zhumadian Second People's Hospital from September 2022 to February 2024 were collected and randomly divided into a study group and a control group,with 53 patients in each group.Patients in the control group were treated with low-dose olanzapine,while those in the study group were treated with low-dose olanzapine combined with lurasidone.Both groups of patients were treated for 8 weeks,and the Scale for Assessment of Positive Symptoms(SAPS),the Scale for Assessment of Negative Symptoms(SANS),glucose and lipid metabolism indicators(total cholesterol[TC],triglycerides[TG],low-density lipoprotein cholesterol[LDL],fasting blood glucose[FBG],glycated hemoglobin[HbA1c],high-density lipoprotein cholesterol[HDL]),prolactin levels,and Montreal Cognitive Assessment(MoCA)scores were compared between the two groups of patients.The incidence of adverse reactions during treatment was also compared.Results Before treatment,there was no statistically significant difference in SAPS and SANS scores between the two groups of patients(P>0.05);after 8 weeks of treatment,the SAPS and SANS scores of both groups of patients decreased compared to those before treatment,and the scores of the study group were(45.26±2.80)points and(46.52±9.08)points,significantly lower than(59.20±3.72)points and(55.28±12.49)points of the control group,with statistically significant differences(P<0.05).Before treatment,there was no statistically significant difference in the levels of TC,TG,LDL,FBG,HbA1c,HDL,and prolactin between the two groups of patients(P>0.05);after 8 weeks of treatment,the levels of TC,TG,LDL,FBG,HbA1c,and prolactin in both groups of patients increased,while HDL decreased,with statistically significant differences(P<0.05);there was no statistically significant difference in the indicators between the two gro

关 键 词：精神分裂症 奥氮平 鲁拉西酮 疗效 催乳素 

分 类 号：R749.3[医药卫生—神经病学与精神病学]