黄芪活性成分调控Th17/Treg细胞免疫平衡作用的研究进展  

Progress of research on effect of active ingredients of Astragalus membranaceus on regulation of Th17/Treg cell immune balance

作　　者：黄武祯 陈斯宁[1] 黎展华 HUANG Wu-zheng;CHEN Si-ning;LI Zhan-hua(Graduate School of Guangri University of Traditional Chinese Medicine,Nanning,Guangri 530000,China;不详)

机构地区：[1]广西中医药大学研究生院,广西南宁530000 [2]广西中医药大学附属瑞康医院呼吸与危重症医学科,广西南宁530000

出　　处：《中华医院感染学杂志》2024年第22期3515-3520,共6页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(82360908)。

摘　　要：本文综述了黄芪活性成分在调控(辅助性T细胞17/调节性T细胞)Th17/Treg细胞免疫平衡方面的研究进展。黄芪作为一种传统草药,具有广泛的药理活性和临床应用价值。黄芪中的活性成分黄芪多糖(APS)、黄芪甲苷具有显著的免疫调节效果,能够抑制Th17细胞的分化和功能,并增加Treg细胞的数量和功能。通过调节免疫细胞的信号通路、抑制炎症因子的产生以及调节免疫耐受等机制影响Th17/Treg细胞免疫平衡,抑制自身免疫性疾病、过敏性疾病和感染性疾病等存在的过度免疫应激病理过程,减轻炎症反应。因此,黄芪及其制剂、活性成分具有潜力成为治疗感染性炎症疾病、变态反应性疾病、炎症性肠病及自身免疫性疾病的候选药物。然而,仍需进一步深入研究黄芪活性成分的作用机制以及其在临床应用中的安全性和有效性,为黄芪注射液、黄芪颗粒等中成药制剂扩大适应证和临床推广提供理论基础。The progress of research on the effect of active ingredients of Astragalus membranaceus on regulation of immune balance of helper T cell 17/regulatory T cell(Th17/Treg)was reviewed in the article.As a traditional herbal medicine,Astragalus membranaceus has a wide range of pharmacological activities and clinical application value.The active ingredients Astragalus polysaccharides and Astragaloside have remarkable effect on immune regulation,inhibit the differentiation and function of Th17 cell,and increase the number and function of the Treg cell.They affect the immune balance of Th17/Treg cell,inhibit the pathological process of excessive immune stress of autoimmune disease,allergic disease and infectious disease,and alleviate the inflammatory response by regulating signaling pathways of immune cells,inhibiting the emergence of anti-inflammatory factors and regulating immune tolerance.Therefore,Astragalus membranaceus and its preparations as well as active ingredients hold the potential for alternative drugs for treatment of infectious inflammatory diseases,allergic diseases,inflammatory bowel diseases and autoimmune diseases.It is necessary to further explore the action mechanisms of the active ingredients of Astragalus membranaceus and safety and effectiveness in clinical application so as to provide theoretical bases for expansion of Chinese patent preparations such as Astragalus injection and Astragalus granules and clinical promotion.

关 键 词：黄芪活性成分 辅助性T细胞17/调节性T细胞细胞免疫平衡 作用机制 炎症 感染 综述 

分 类 号：R229[医药卫生—中医基础理论]