结直肠癌中医辨证分型与血清miR-29、TSGF、TGF-β1水平的相关性研究  

Study on the correlation between TCM syndrome differentiation of colorectal cancer and serum levels of miR-29,TSGF and TGF-β1

作　　者：李蕾 蒋文婷 高超 LI Lei;JIANG Wenting;GAO Chao(First Clinical School of Xuzhou Medical University,Xuzhou Jiangsu 221002,China;Department of Oncology,Affiliated Hospital of Xuzhou Medical University,Xuzhou Jiangsu 221004,China)

机构地区：[1]徐州医科大学第一临床医学院,江苏徐州221002 [2]徐州医科大学附属医院肿瘤内科,江苏徐州221004

出　　处：《四川中医》2024年第11期10-13,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:分析结直肠癌患者中医辨证分型与其血清微小RNA-29(miR-29)、肿瘤特异性生长因子(TSGF)及转化生长因子β1(TGF-β1)水平的相关性。方法:收集医院2021年9月~2023年9月收治的134例结直肠癌患者的临床资料进行回顾性分析,根据四诊资料对患者进行中医辨证分型,比较不同中医证型患者血清miR-29、TSGF及TGF-β1水平的差异,采用Logistic回归分析各中医证型与血清miR-29、TSGF、TGF-β1的相关性。结果:134例结直肠癌患者中医辨证分型由高至低分别为脾虚气滞证64例,占47.76%;湿热蕴结证39例,占29.10%;瘀毒内阻证31例,占23.13%;miR-29表达水平在不同组别中的比较为:瘀毒内阻组<湿热蕴结组<脾虚气滞组(P<0.05);TSGF及TGF-β1水平在不同组别中的比较均为:瘀毒内阻组>湿热蕴结组>脾虚气滞组(P<0.05);Logistic回归分析结果显示,瘀毒内阻症与miR-29呈负相关(P<0.05),与TGF-β1及TSFG呈正相关(P<0.05)。结论:结直肠癌患者的中医辨证分型与其血清miR-29、TSGF及TGF-β1具有一定相关性,可为中医辨证分型提供依据。Objective:To analyze the correlation between TCM syndrome differentiation and serum microRNA-29(miR-29),tumor specific growth factor(TSGF)and transforming growth factor-β1(TGF-β1)levels in patients with colorectal cancer.Methods:The clinical data of 134patients with colorectal cancer admitted to our hospital from September 2021to September 2023were retrospectively analyzed.According to the four diagnostic data,the patients were divided into TCM syndromes.The differences of serum miR-29,TSGF and TGF-β1levels in patients with different TCM syndromes were compared.Logistic regression was used to analyze the correlation between TCM syndromes and serum miR-29,TSGF and TGF-β1.Results:134cases of colorectal cancer patients with TCM syndrome differentiation from high to low were 64cases of spleen deficiency and qi stagnation syndrome,accounting for 47.76%;39cases of damp-heat accumulation syndrome,accounting for 29.10%;there were 31cases of blood stasis syndrome,accounting for 23.13%.The expression level of miR-29in different groups was compared as follows:blood stasis and toxin internal resistance group<damp-heat accumulation group<spleen deficiency and qi stagnation group(P<0.05);the comparison of TSGF and TGF-β1levels in different groups was as follows:blood stasis and toxin obstruction group>damp-heat accumulation group>spleen deficiency and qi stagnation group(P<0.05);logistic regression analysis showed that internal obstruction of blood stasis and toxin was negatively correlated with miR-29(P<0.05),and positively correlated with TGF-β1and TSFG(P<0.05).Conclusion:There is a certain correlation between TCM syndrome differentiation and serum miR-29,TSGF and TGF-β1in patients with colorectal cancer,which can provide a basis for TCM syndrome differentiation.

关 键 词：结直肠癌 中医辨证分型 微小RNA-29 肿瘤特异性生长因子 转化生长因子β1 

分 类 号：R735.35[医药卫生—肿瘤]