八珍汤联合化疗方案治疗对乳腺癌患者免疫功能、癌因性疲乏及血清细胞因子水平的影响  

Effects of Bazhen Decoction combined with chemotherapy on immune function, cancer-relatedfatigue and serum cytokines in patients with breast cancer

作　　者：顾卫卫 郭雪美 倪冲 陈坤燕 GU Weiwei;GUO Xuemei;NI Chong(Qidong People s Hospital/Qidong Institute of Liver Cancer Prevention and Treatment/Department of Pharmacy,Qidong Hospital affiliated to Nantong University,Qidong Jiangsu 226200,China)

机构地区：[1]启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院药剂科,江苏启东226200 [2]启东市人民医院/启东肝癌防治研究所/南通大学附属启东医院肿瘤内科,江苏启东226200

出　　处：《四川中医》2024年第11期162-166,共5页Journal of Sichuan of Traditional Chinese Medicine

基　　金：南通市卫生健康委员会(QNZ2022087)。

摘　　要：目的:探析八珍汤联合化疗方案治疗对乳腺癌患者免疫功能、癌因性疲乏(CRF)及血清细胞因子水平的影响。方法:纳入79例于2023年3月~2024年1月在我院接受治疗的乳腺癌患者,按照治疗方式的不同分为对照组(35例)行吡柔比星+环磷酰胺+多西他赛化疗治疗,治疗组(44例)在其基础上联用八珍汤口服,治疗8周后,对比两组临床疗效、中医证候积分、CRF(Piper疲乏修订量表)、免疫功能[诱导性T细胞(CD4^(+) )、抑制性T细胞(CD8^(+) )、自然杀伤细胞(NK细胞)]、细胞炎性因子[肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)],观察两组化疗后不良反应情况。结果:治疗后,治疗组治疗有效率54.55%与对照组42.86%无显著差异( P >0.05);两组中医证候积分、CRF评分均降低,治疗组低于对照组( P <0.05);治疗后,对照组CD4^(+) 、NK细胞水平降低,CD8^(+) 水平升高,治疗组CD4^(+) 、NK细胞水平升高,CD8^(+) 水平降低( P <0.05);两组TNF-α、IFN-γ、IL-6、IL-10均下降,治疗组低于对照组( P <0.05);两组患者化疗后不良反应发生情况无显著差异( P >0.05)。结论:对乳腺癌患者行八珍汤联合化疗方案的治疗方式能够有效改善患者疲乏症状,降低炎症反应,增强免疫功能。Objective: To explore the effects of Bazhen Decoction combined with chemotherapy on immune function, cancer-relatedfatigue(CRF) and serum cytokines in patients with breast cancer. Methods: A total of 79patients with breast cancer treated in the hospital were enrolled between March 2023and January 2024. According to different treatment methods, they were divided into control group(35cases, chemotherapy with pirarubicin^(+) cyclophosphamide^(+) docetaxel) and treatment group(44cases, Bazhen Decoction on basis of control group). After 8weeks of treatment, clinical curative effect, scores of TCM syndromes, CRF(revised Piper fatigue scale), immune function [induced T cells(CD4^(+) ), inhibitory T cells(CD8^(+) ), natural killer cells(NK cells)] and cellular inflammatory factors [tumor necrosis factor-α(TNF-α), interferon-γ(IFN-γ), interleukin 6(IL-6), interleukin-10(IL-10)] were compared between the two groups. The adverse reactions after chemotherapy in the two groups were observed. Results: After treatment, there was no significant difference inresponse rate of treatment between treatment group and control group(54.55% vs 42.86%, P >0.05). After treatment,scores of TCM syndromes and CRF were decreased in both groups, which were lower in treatment group than control group( P <0.05). After treatment, levels of CD4^(+) and NK cells were decreased, while CD8^(+) was increased in control group. Treatment groups, levels of CD4^(+) and NK cells were increased, while CD8^(+) was decreased in treatment group( P <0.05). After treatment, levels of TNF-α, IFN-γ, IL-6and IL-10were decreased in both groups, which were lower in treatment group than control group( P <0.05). There was no significant difference in the occurrence of adverse reactions between the two groups after chemotherapy( P >0.05). Conclusion: Bazhen Decoction combined with chemotherapy in breast cancer patients can effectively improve fatigue symptoms, reduce inflammatory response and enhance immune function.

关 键 词：乳腺癌 化疗 八珍汤 免疫功能 癌因性疲乏 炎症反应 

分 类 号：R737.9[医药卫生—肿瘤]