牙龈卟啉单胞菌在肺癌中的相关研究与进展  

Research and Progress on the Association of Porphyromonas gingivalis with Lung Cancer

作　　者：尹媛媛 张杰[1,2] 郭强 沈诚 Yuanyuan YIN;Jie ZHANG;Qiang GUO;Cheng SHEN(Department of Thoracic Surgery,West China Hospital,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;West China School of Nursing,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院胸外科,成都610041 [2]四川大学华西护理学院,成都610041 [3]四川大学,华西口腔医院,口腔疾病防治全国重点实验室,成都610041

出　　处：《中国肺癌杂志》2024年第10期799-804,共6页Chinese Journal of Lung Cancer

摘　　要：牙龈卟啉单胞菌(Porphyromonas gingivalis)是引发牙周炎的一种核心病原微生物,不仅与慢性牙周炎等口腔疾病密切相关,近年来被发现与癌症的发生、发展及预后均具有显著相关性。肺癌作为全球发病与死亡人数均为首位的恶性肿瘤,一直都是研究者关注的重点与热点。肺癌的发病原因复杂,涉及多种因素,包括吸烟、职业因素、空气污染、电离辐射、饮食与营养、遗传因素等。研究者们也开始关注到口腔微生物群与全身健康的关系,特别是与肺癌之间的联系。本文总结了牙龈卟啉单胞菌在肺癌中的相关研究最新进展,主要包括病因、致病机制等,并探讨了其作为肺癌潜在治疗靶点的可能性,旨在为肺癌的预防和治疗策略提供新的思路与方向。Porphyromonas gingivalis is a key pathogenic microorganism that triggers periodontitis.It is closely associated with oral diseases such as chronic periodontitis and recently found to have a significant correlation with the occurrence,progression,and prognosis of cancer.As the leading malignant tumor in terms of both incidence and mortality worldwide,lung cancer has always been a focus and hotspot of research.The causes of lung cancer are complex and involve multiple factors,including smoking,occupational factors,air pollution,ionizing radiation,diet and nutrition,genetic factors,etc.Researchers have also begun to pay attention to the relationship between oral microbiota and overall health,especially the link with lung cancer.The article summarizes the latest advancements in research on Porphyromonas gingivalis in lung cancer,primarily encompassing etiology and pathogenic mechanisms,and explores its potential as a therapeutic target for lung cancer,aiming to provide new insights and directions for lung cancer prevention and treatment strategies.

关 键 词：牙龈卟啉单胞菌 肺肿瘤 相关性 

分 类 号：R734.2[医药卫生—肿瘤]