Linking fatty liver diseases to hepatocellular carcinoma by hepatic stellate cells  

作　　者：Liang’en Chen Xiangshi Ye Lixian Yang Jiangsha Zhao Jia You Yuxiong Feng 

机构地区：[1]Zhejiang Provincial Key Laboratory of Pancreatic Disease,First Affiliated Hospital,and Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou,China [2]Cancer Center,Zhejiang University,Hangzhou,China [3]Cancer Center,Department of Radiation Oncology,Zhejiang Provincial People’s Hospital(Hangzhou Medical College),Hangzhou,China [4]School of Life Sciences,Westlake University,Hangzhou,China

出　　处：《Journal of the National Cancer Center》2024年第1期25-35,共11页癌症科学进展（英文）

基　　金：supported by grants from the Ministry of Science and Technology of the People’s Republic of China(grant number:2020YFA0803300);the National Natural Science Foundation of China(grant numbers:32270783,32100949,32300642);Figures were prepared using Figdraw。

摘　　要：Hepatic stellate cells(HSCs),a distinct category of non-parenchymal cells in the liver,are critical for liver homeostasis.In healthy livers,HSCs remain non-proliferative and quiescent.However,under conditions of acute or chronic liver damage,HSCs are activated and participate in the progression and regulation of liver diseases such as liver fibrosis,cirrhosis,and liver cancer.Fatty liver diseases(FLD),including nonalcoholic(NAFLD)and alcoholrelated(ALD),are common chronic inflammatory conditions of the liver.These diseases,often resulting from multiple metabolic disorders,can progress through a sequence of inflammation,fibrosis,and ultimately,cancer.In this review,we focused on the activation and regulatory mechanism of HSCs in the context of FLD.We summarized the molecular pathways of activated HSCs(aHSCs)in mediating FLD and their role in promoting liver tumor development from the perspectives of cell proliferation,invasion,metastasis,angiogenesis,immunosuppression,and chemo-resistance.We aimed to offer an in-depth discussion on the reciprocal regulatory interactions between FLD and HSC activation,providing new insights for researchers in this field.

关 键 词：Hepatic stellate cell Fatty liver disease Hepatocellular carcinoma Liver fibrosis 

分 类 号：R57[医药卫生—消化系统]