二维剪切波弹性成像联合TRIM29、GDF-15、IL-37水平对乳腺浸润性导管癌腋窝淋巴结转移的诊断价值  

The Diagnostic Value of Two-dimensional Shear Wave Elastography Combined with TRIM29,GDF-15,IL-37 Levels for Axillary Lymph Node Metastasis in Invasive Ductal Carcinoma of Breast

作　　者：徐小艳[1] XU Xiaoyan(Department of Ultrasound,the First People's Hospital of Fuzhou,Fuzhou 344000,China)

机构地区：[1]抚州市第一人民医院超声科,江西抚州344000

出　　处：《中国医学创新》2024年第31期150-154,共5页Medical Innovation of China

摘　　要：目的:本研究旨在探讨二维剪切波弹性成像(2D-SWE)与TRIM29蛋白、生长分化因子-15(GDF-15)、白细胞介素-37(IL-37)表达水平在乳腺浸润性导管癌(invasive ductal carcinoma,IDC)腋窝淋巴结转移(axillary lymph node metastasis,ALNM)诊断中的应用价值及其联合诊断的效果。方法:本研究于2022年1月—2024年1月在抚州市第一人民医院进行,共纳入207例乳腺IDC患者为研究对象,根据是否并发ALNM进行分组,出现ALNM的114例患者纳入研究组,未出现ALNM的93例患者纳入对照组。对比两组患者2D-SWE评分和TRIM29、GDF-15、IL-37表达水平,进行乳腺IDC患者发生ALNM的危险因素分析。使用受试者操作特征(ROC)曲线评估各项指标及联合应用对ALNM的诊断效能。结果:研究组患者腋窝淋巴结2D-SWE评分显著高于对照组,差异有统计学意义(P<0.05)。研究组患者IL-37水平显著低于对照组,TRIM29、GDF-15水平均显著高于对照组(P<0.05)。根据患者的ALNM诊断结果,ALNM作为应变量(是=1,否=0),将患者各项检测指标水平均作为自变量纳入logistic多因素回归分析表明,2D-SWE评分、TRIM29、GDF-15和IL-37均是患者腋窝淋巴结转移的影响因素(P<0.05)。采用ROC曲线对2D-SWE评分、TRIM29、GDF-15和IL-37水平的诊断效能进行评估和比较,联合检测的曲线下面积达0.963。结论:2D-SWE评分、TRIM29、GDF-15和IL-37水平与并发ALNM密切相关,几项指标联合诊断ALNM具有更高的敏感度、特异度。Objective:To explore the application value and the combined diagnostic effect of two-dimensional shear wave elastography(2D-SWE)and TRIM29 protein expression level,GDF-15,IL-37 levels in the diagnosis of axillary lymph node metastasis(ALNM)in invasive ductal carcinoma(IDC)of the breast.Method:This study was conducted in the First People's Hospital of Fuzhou from January 2022 to January 2024.A total of 207 patients with breast IDC were included as the research objects.According to whether they were complicated with ALNM,114 patients with ALNM were included in the study group,and 93 patients without ALNM were included in the control group.The 2D-SWE scores and the expression levels of TRIM29,GDF-15,and IL-37 between the two groups were compared,the risk factors for the occurrence of ALNM in breast IDC patients were analyzed.The diagnostic efficiency of these indicators and their combined use for ALNM were evaluated using receiver operating characteristic(ROC)curves.Result:The axillary lymph node 2D-SWE scores of the study group were significantly higher than those of the control group,with a statistically significant difference(P<0.05).The levels of IL-37 were significantly lower in the study group,while TRIM29 and GDF-15 levels were significantly higher compared to the control group(P<0.05).According to the diagnosis of ALNM of the patient,ALNM was used as a dependent variable(yes=1,no=0),and the levels of each test index of the patient were included as independent variables in the logistic multivariate regression analysis.The results showed that 2D-SWE score,TRIM29,GDF-15 and IL-37 were all influencing factors for ALNM(P<0.05).The diagnostic efficacy of 2D-SWE scores,TRIM29,GDF-15,and IL-37 levels were evaluated and compared using ROC curves,with the area under the curve for combined testing reaching 0.963.Conclusion:The levels of 2D-SWE scores,TRIM29,GDF-15,and IL-37 are closely associated with concurrent ALNM.The combined diagnostic use of these indicators provides higher sensitivity,specificity,for diagnosing

关 键 词：二维剪切波弹性成像 TRIM29蛋白 浸润性导管癌 淋巴结转移 诊断价值 

分 类 号：R737.9[医药卫生—肿瘤] R445.1[医药卫生—临床医学]