T2期胆囊癌肝切除必要性的Meta分析  

Meta-analysis on the necessity of hepatectomy for T2 stage gallbladder cancer

作　　者：孙喆 徐新生 赵宏志[1] SUN Zhe;XU Xin-sheng;ZHAO Hong-zhi(Tianjin Hospital of Integrated Traditional Chinese and Western Medicine,Tianjin(300100),China)

机构地区：[1]天津市中西医结合医院,天津300100

出　　处：《中国中西医结合外科杂志》2024年第6期883-888,共6页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：天津市卫健委中西医结合课题(2023095)。

摘　　要：目的:通过Meta分析研究肝切除术对于T2期胆囊癌患者预后的影响。方法:检索Pubmed、Embase、Web of Science、Cochrane Library、中国知网、万方、维普网站。英文检索词汇包括:gallbladder carcinoma,surgery,cholecystectomy,radical cholecystectomy,hepatectomy,liver resection。中文检索词汇包括:胆囊癌、手术、胆囊切除术、根治性胆囊切除、肝切除。比较两组患者的总体生存率、无病生存率、术后并发症和术后30 d死亡率。使用RevMan 5.4统计软件对数据进行Meta分析。结果:共有20个研究包含3222例患者被纳入,其中1959例患者进行了肝切除,1263例未进行肝切除。Meta分析结果显示,肝切除组与非肝切除组患者术后总生存率[风险比(RR)=0.93,95%CI:0.77~1.12,P=0.44],术后无病生存率(RR=1.11,95%CI:0.84~1.47,P=0.45),术后并发症发生率(RR=2.00,95%CI:0.71~5.62,P=0.19)及术后30 d内死亡率(RR=0.90,95%CI:0.10~8.02,P=0.92)均无显著统计学差异。结论:对于T2期胆囊癌的患者,并不能从肝切除术中获益。Objective To investigate the impact of hepatectomy on the prognosis of patients with T2 stage gallbladder cancer through Meta-analysis.Methods Databases including PubMed,Embase,Web of Science,Cochrane Library,CNKI,Wanfang Database,and VIP Database were searched.The search terms included:gallbladder carcinoma,surgery,cholecystectomy,radical cholecystectomy,hepatectomy,liver resection.Comparative analysis was conducted on indicators such as overall survival,disease-free survival,postoperative complication rate,and mortality within 30 days after surgery between the hepatectomy group and the non-hepatectomy group.Meta-analysis was performed using RevMan 5.4 software.Results A total of 20 studies involving 3222 patients were included,with 1959 patients in the hepatectomy group and 1263 patients in the non-hepatectomy group.Meta-analysis results showed no significant statistical differences in postoperative overall survival rate(RR=0.93,95%CI:0.77-1.12,P=0.44),postoperative disease-free survival rate(RR=1.11,95%CI:0.84-1.47,P=0.45),postoperative complication rate(RR=2.00,95%CI:0.71-5.62,P=0.19,and mortality within 30 days after surgery(RR=0.90,95%CI:0.10-8.02,P=0.92)between the hepatectomy group and the non-hepatectomy group.Conclusion Hepatectomy does not benefit patients with T2 stage gallbladder cancer.

关 键 词：胆囊癌 胆囊切除 肝切除 

分 类 号：R735.8[医药卫生—肿瘤] R657.4[医药卫生—临床医学]