胆囊腺瘤癌变诊疗新进展  

Advances in diagnosis and treatment of canceration of gallbladder adenoma

作　　者：耿志丹 袁海霞 俞清 GENG Zhi-dan;YUAN Hai-xia;YU Qing(Department of Ultrasound,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Ultrasound,Qingpu Branch of Zhongshan Hospital,Fudan University,Shanghai 201799,China;Department of Ultrasound,Shanghai Geriatric Medical Center,Shanghai 201104,China;Department of Ultrasound,Zhongshan Hospital(Xiamen Branch),Fudan University,Xiamen 361015,Fujian Province,China)

机构地区：[1]复旦大学附属中山医院超声科,上海200032 [2]复旦大学附属中山医院青浦分院超声科,上海201799 [3]上海市老年医学中心超声科,上海201104 [4]复旦大学附属中山医院厦门医院超声科,厦门361015

出　　处：《复旦学报（医学版）》2024年第6期1009-1015,共7页Fudan University Journal of Medical Sciences

基　　金：上海市科委医疗创新专项(21Y11911200);福建省自然科学基金(2023J011696)。

摘　　要：胆囊腺瘤为起源于胆囊黏膜上皮的良性肿瘤,被认为是胆囊癌(gallbladder cancer,GBC)的前期病变,其恶变可能在相对较短的时间内发生。目前对于胆囊腺瘤癌变的病理过程及分子机制仍存在争议;超声和CT广泛应用于胆囊疾病的检查,而超声造影(contrast-enhanced ultrasound,CEUS)、高帧率超声造影(high-frame-rate contrast-enhanced ultrasound,H-CEUS)等技术的应用提高了诊断精度。本文对胆囊腺瘤癌变的临床病理学特征、影像表现、基因表达、治疗和临床预后进行文献总结。Gallbladder adenoma,a benign tumor of mucosal epithelial origin,is considered to be a precancer to gallbladder cancer(GBC),and its malignant transformation may occur in a relatively short time.The pathological process and molecular mechanism of gallbladder adenoma carcinogenesis are still controversial;ultrasound and CT are widely used to examine gallbladder diseases,and the application of contrast-enhanced ultrasound(CEUS)and high-frame-rate contrast-enhanced ultrasound(H-CEUS)has improved the diagnostic accuracy.In this paper,we summarize the literature on the clinicopathological features,imaging manifestations,gene expression,treatment,and clinical prognosis of gallbladder adenoma carcinogenesis.

关 键 词：胆囊腺瘤 超声 超声造影(CEUS) 

分 类 号：R735.8[医药卫生—肿瘤]