IDH1和ATRX在胶质瘤中的表达及其预后相关性分析  

Expression of IDH1 and ATRX in Gliomas and Their Prognostic Correlation Analysis

作　　者：梁华 金珊 赵冬[1] LIANG Hua;JIN Shan;ZHAO Dong(Department of Neurosurgery,the First Affiliated Hospital of Shihezi University,Xinjiang Shihezi,832008;Department of Pathology,the First Affiliated Hospital of Shihezi University,Xinjiang Shihez,832008)

机构地区：[1]石河子大学第一附属医院神经外科,新疆石河子832008 [2]石河子大学第一附属医院病理科,新疆石河子832008

出　　处：《农垦医学》2024年第4期289-296,301,共9页Journal of Nongken Medicine

摘　　要：目的:通过生物信息学技术分析IDH1和ATRX在泛癌及胶质瘤中的表达和预后价值,并探索与免疫浸润的关系。方法:从UCSC Xena数据库下载癌症基因组图谱计划数据库中33种肿瘤的数据,分析IDH1和ATRX在33种肿瘤中的表达和预后价值。利用TISIDB数据库计算免疫浸润丰度,分析IDH1和ATRX胶质瘤中的表达及其与预后相关性。结果:IDH1和ATRX在多种肿瘤中高表达,且与免疫浸润相关,同时IDH1和ATRX在胶质瘤中表达具有差异性,且与生存率显著相关。结论:IDH1和ATRX可作为胶质瘤生存、预后及免疫浸润的生物标志物,为胶质瘤治疗提供新的思路。Objective:To analyze the expression and prognostic value of IDH1 and ATRX in pan-cancer and gliomas using bioinformatics technology,and explore their relationship with immune infiltration.Methods:Download data for 33 types of tumors from the Cancer Genome Atlas program database in the UCSC Xena database,analyze the expression and prognostic value of IDH1 and ATRX in the 33 types of tumors.Utilize the TISIDB database to calculate immune infiltration abundance,analyze the expression of IDH1 and ATRX in gliomas and their correlation with prognosis.Results:IDH1 and ATRX are highly expressed in multiple tumors,and are associated with immune infiltration.Meanwhile,the expression of IDH1 and ATRX in gliomas varies and is significantly correlated with survival rate.Conclusion:IDH1 and ATRX can serve as biomarkers for the survival,prognosis,and immune infiltration of gliomas,providing new insights into the treatment of gliomas.

关 键 词：IDH1 ATRX 生物信息学 预后 免疫浸润 

分 类 号：R739.41[医药卫生—肿瘤]