基于口腔特殊环境的水凝胶创面敷贴设计策略  

Design strategy of hydrogel wound dressings based on oral special environment

作　　者：许瑞 潘钊 邹多宏[3] Xu Rui;Pan Zhao;Zou Duohong(College&Hospital of Stomatology,Anhui Medical University,Key Laboratory of Oral Diseases Research of Anhui Province,Hefei 230032,China;Hangzhou Institute of Medicine,Chinese Academy of Sciences,Hangzhou 310022,China;Dept.of Oral Surgery,Shanghai Ninth People’s Hospital,Shanghai JiaoTong University School of Medicine,College of Stomatology,Shanghai JiaoTong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai 200011,China)

机构地区：[1]安徽医科大学口腔医学院,安徽医科大学附属口腔医院,安徽省口腔疾病研究重点实验室,合肥230032 [2]中国科学院杭州医学研究所,杭州310022 [3]上海交通大学医学院附属第九人民医院口腔外科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海200011

出　　处：《华西口腔医学杂志》2024年第6期689-698,共10页West China Journal of Stomatology

基　　金：国家自然科学基金(92368111,32171347);上海市卫生健康委员会卫生健康学科带头人培养计划(2022XD038);上海交通大学医学院生物材料与再生医学研究院联合攻关重点项目(2022LHA04);上海交通大学医学院附属第九人民医院原创探索项目(JYYC007)

摘　　要：外伤、手术、疾病以及化学刺激等造成的口腔内创伤为患者带来疼痛并增加感染风险。有效的创面保护及修复对提高患者生活质量和维护口腔健康至关重要。敷贴材料通过阻隔创面与口腔环境,为创面提供理想的愈合条件。然而在口腔高度湿润且微生物富集的动态环境下,伤口敷贴如何保持性能稳定仍面临巨大挑战。水凝胶因其良好的生物安全性以及性能多样性展现出广阔的应用前景,成为解决口腔创面保护及修复难题的研究热点。本文探讨水凝胶敷贴克服口腔特殊环境实现持久黏附及功能发挥的设计策略,以期为理想的口腔创面屏障材料设计提供新思路。Oral wounds caused by injuries,surgeries,diseases,and chemical irritations bring pain to the patient and increase the risk of infection.Effective wound protection and repair are crucial for improving patients’quality of life and maintaining oral health.Wound dressings provide ideal healing conditions by isolating the wound from the oral environment.However,in the highly moist,microbiologically rich environment of the oral cavity,maintaining the stability of wound dressings remains a considerable challenge.Hydrogels show promising prospects for oral applications and are gradually becoming a research hotspot for addressing the challenges of oral wound protection and repair due to their excellent biocompatibility and versatile performance.In this paper,the current design strategies of hydrogel wound dressings that overcome the unique oral environment,achieve sustained adhesion and fulfill their functions are reviewed to provide new insights for the design of ideal oral wound barrier materials.

关 键 词：口腔创面 水凝胶敷贴 湿态粘接 机械性能 药物控释 

分 类 号：R783.1[医药卫生—口腔医学]