帕金森病合并糖尿病患者感觉障碍与脑血流储备和血浆miR-331-5p的相关性研究  

Correlation between Sensory Disturbance,Cerebral Blood Flow Reserve and Plasma miR-331-5p in Patients with Parkinson's Disease and Diabetes

作　　者：张晓杰 艾伟平 赵义凡 陈素艳 潘妍婷[4] ZHANG Xiao-jie;AI Wei-ping;ZHAO Yifan;CHEN Su-yan;PAN Yan-ting(The First Department of Neurology,Zhangjiakou First Hospital,Zhangjiakou 075000,China;The First Department of Neurosurgery,Zhangjiakou First Hospital,Zhangjiakou 075000,China;Department of Neuroelectrophysiology,Zhangjiakou First Hospital,Zhangjiakou 075000,China;Department of Neurology,the First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China)

机构地区：[1]张家口市第一医院神经内一科,张家口075000 [2]张家口市第一医院神经外一科,张家口075000 [3]张家口市第一医院电生理科,张家口075000 [4]河北北方学院附属第一医院神经内科,张家口075000

出　　处：《中国临床神经科学》2024年第5期507-513,535,共8页Chinese Journal of Clinical Neurosciences

基　　金：2023年河北省医学科学研究课题青年科技课题(编号:20232061);张家口市重点研发计划项目(编号,2221125D)。

摘　　要：目的分析帕金森病(PD)合并糖尿病患者感觉障碍与脑血流储备和血浆miR-331-5p的相关性。方法选取2021年6月至2023年6月门诊或住院的40例PD合并糖尿病患者为PD合并糖尿病组,同期纳入与PD合并糖尿病患者相匹配的40例PD患者为PD组,另选择40例健康者为对照组。比较3组的脑血流储备和血浆miR-331-5p水平。采用BPI、AHRS、IRLSRS量表评估各组疼痛、嗅觉障碍及不宁腿综合征情况,分析3项指标的相关性。结果PD合并糖尿病组、PD组、对照组双侧大脑中动脉、大脑后动脉、基底动脉的脑血流速度(CBFV)值依次升高,血浆miR-331-5p水平依次降低(P<0.05);PD合并糖尿病组的疼痛、嗅觉障碍、不宁腿综合征发生率均高于PD组(P<0.05)。伴疼痛患者双侧大脑中动脉、大脑后动脉及基底动脉CBFV低于非疼痛患者,血浆miR-331-5p水平高于非疼痛患者(P<0.05);伴不宁腿综合征患者血浆miR-331-5p水平高于非不宁腿综合征患者(P<0.05);伴不宁腿综合征患者脑血流储备与非不宁腿综合征患者比较,差异无显著性(P>0.05);嗅觉障碍患者脑血流储备、血浆miR-331-5p水平与非嗅觉障碍患者比较差异均无显著性(均P>0.05)。相关性分析显示,PD合并糖尿病组的疼痛与脑血流储备指标均呈负相关(r<0,P<0.05),与miR-331-5p呈正相关(r>0,P<0.05);伴不宁腿综合征与miR-331-5p呈正相关(r>0,P<0.05)。结论PD合并糖尿病患者存在感觉障碍、脑血流储备功能下降,血浆miR-331-5p水平升高,且血流储备功能、血浆mi R-331-5p水平对PD合并糖尿病患者的感觉障碍发生存在一定程度的影响。Aim To analyze the correlation between sensory disturbance,cerebral blood flow reserve and plasma miR-331-5p in patients with Parkinson's disease(PD)and diabetes.Methods From June 2021 to June 2023,40 patients with PD complicated with diabetes were selected as a PD complicated with diabetes group,40 patients with PD matched with the PD complicated with diabetes group were selected as a PD group,and 40 healthy people were selected as a control group.The cerebral blood flow reserve and plasma mi R-331-5p levels were compared among the three groups.The BPI,AHRS and IRLSRS scales were used to evaluate the pain,olfactory dysfunction and restless leg syndrome in each group,and the correlation among the three indicators was analyzed.Results The cerebral blood flow velocity(CBFV)values of bilateral middle cerebral artery,posterior cerebral artery and basilar artery in the PD group with diabetes,the PD group and the control group increased in turn,and the level of plasma mi R-331-5p decreased in turn(P<0.05).The incidence of pain,olfactory disorder and restless leg syndrome in the PD group with diabetes was higher than that in the PD group(P<0.05).The CBFV of bilateral middle cerebral artery,posterior cerebral artery,and basal artery with pain symptoms was lower than that of non pain patients,and the plasma mi R-331-5p level was higher than that of non pain patients(P<0.05).The plasma mi R-331-5p levels in patients with restless leg syndrome were higher than those in non restless leg syndrome(P<0.05).There was no significant difference in cerebral blood flow reserve between patients with restless leg syndrome and those without restless leg syndrome(P>0.05).Cerebral blood flow reserve and plasma mi R-331-5p level in patients with olfactory dysfunction were compared with those in patients with non-olfactory dysfunction(P>0.05).Correlation analysis showed that the pain of PD patients with diabetes was negatively correlated with cerebral blood flow reserve index(r<0,P<0.05).and positively correlated with mi R-331-5p(r>0,P<0.0

关 键 词：帕金森病 糖尿病 感觉障碍 脑血流储备 血浆miR-331-5p 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]