基于改进关联规则与logistic回归算法集成的2型糖尿病中医证型鉴别研究  

Study on TCM Syndromes Differentiation of Type 2 Diabetes Based on the Integration of Improved Association Rules and Logistic Regression Algorithm

作　　者：刘红萍 杨杰 庞国明[3] 邢颖 李鹏辉 吴敏 温宵宵 李洪皎 文天才[1,2] LIU Hongping;YANG Jie;PANG Guoming;XING Ying;LI Penghui;WU Min;WEN Xiaoxiao;LI Hongjiao;WEN Tiancai(Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Traditional Chinese Medicine Data Center,China Academy of Chinese Medical Sciences,Beijing 100700,China;Kaifeng Traditional Chinese Medicine Hospital,Kaifeng 475000,China;Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中医药信息研究所,北京100700 [2]中国中医科学院中医药数据中心,北京100700 [3]开封市中医院,开封475000 [4]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《医学信息学杂志》2024年第11期43-49,共7页Journal of Medical Informatics

基　　金：国家自然科学基金面上项目(项目编号:82374624);北京市自然科学基金面上项目(项目编号:7232306);中国中医科学院自主选题项目(项目编号:ZZ16-XRZ-107-SJ)。

摘　　要：目的/意义分析2型糖尿病患者中西医特征间的多维交互关系及其对中医辨证的影响。方法/过程基于真实世界电子病历数据,改进传统关联规则算法,增加尊重度指标,筛选重要的中医证型作为因变量进入logistic回归算法,分析中西医临床指标与中医证型的关联。结果/结论基于688例患者得到关联规则112条,其中包含中医证型的有12条。中土壅滞证与超重/肥胖的关联规则尊重度最大,且超重/肥胖患者的中土壅滞证患病率更高。中土壅滞证、合并周围神经病变、合并高血压与超重/肥胖的关联性较强。合并糖尿病肾病患者出现气阴两虚证的可能性更大。Purpose/Significance To analyze the multidimensional interaction between the characteristics of traditional Chinese and western medicine in patients with type 2 diabetes mellitus and its influence on traditional Chinese medicine(TCM)syndrome differentiation.Method/Process Based on the real-world electronic medical record(EMR)data,the traditional association rule algorithm is improved,and the important TCM syndromes are screened out as dependent variables by increasing the respect index,and the logistic regression algorithm is used to explore the influence of traditional Chinese and western medicine indexes on TCM syndromes.Result/Conclusion Based on 688 patients,112 association rules are obtained,of which 12 includes TCM syndromes.The respect of association rules between middle-earth stagnation syndrome and overweight/obesity is the highest,moreover,overweight/obesity patients have a higher prevalence rate of middle-earth stagnation syndrome.There is a strong correlation between middle-earth stagnation syndrome,peripheral neuropathy or hypertension and overweight/obesity.Patients with diabetic nephropathy are more likely to have qi and yin deficiency syndrome.

关 键 词：2型糖尿病 中西医特征 中医证型 关联规则 真实世界研究 

分 类 号：R-058[医药卫生]