苯扎氯铵联合硝呋太尔制霉素改善霉菌性阴道炎患者失眠的效果  

Effect of Benzalkonium Chloride Combined with Nifuratel-nystatin on Insomnia in Patients with Fungal Vaginitis

作　　者：贾瑞侠 余巧铃 张雪彬 叶小飞 JIA Ruixia;YU Qiaoling;ZHANG Xuebin;YE Xiaofei(Gutian County General Hospital,Ningde 352200,China;Anhui Provincial Children′s Hospital,Hefei 230022,China)

机构地区：[1]福建省宁德市古田县总医院,宁德352200 [2]安徽省儿童医院,合肥230022

出　　处：《世界睡眠医学杂志》2024年第9期1944-1947,共4页World Journal of Sleep Medicine

摘　　要：目的:研究霉菌性阴道炎采用苯扎氯铵联合硝呋太尔制霉素治疗对患者失眠的改善效果。方法:回顾2022年5月至2023年5月古田县总医院收治的霉菌性阴道炎患者80例作为研究对象,按照治疗方法不同,分为对照组和观察组,每组40例,对照组采用硝呋太尔制霉素治疗,观察组在对照组基础上联合苯扎氯铵治疗。对2组临床病症恢复、失眠情况[阿森斯失眠量表(AIS)]、舒适度[舒适状况量表(GCQ)]、睡眠质量[匹兹堡睡眠质量指数量表(PSQI)]、生命质量进行评估。结果:与对照组相较,观察组临床各项症状恢复时间更短,AIS评分治疗后5 d、治疗后10 d得分比对照组低,舒适度评分更高,睡眠质量评分中日间功能、睡眠障碍、睡眠效率、药物应用、入睡时间、睡眠时间、睡眠质量得分比对照组低,差异均有统计学意义(均P<0.05)。结论:霉菌性阴道炎采用苯扎氯铵联合硝呋太尔制霉素治疗效果较佳,能够促进病症恢复,改善失眠情况,提高患者舒适度及睡眠质量。Objective:To study the effect of benzalkonium chloride combined with nifuratel-nystatin in improving insomnia in patients with fungal vaginitis.Methods:A total of 80 patients with fungal vaginitis treated at Gutian County General Hospital between May 2022 and May 2023 were retrospectively selected as study subjects.Forty patients treated with nifuratel-nystatin were designated as the control group,and another 40 patients treated with a combination of benzalkonium chloride and nifuratel-nystatin were designated as the observation group.Clinical recovery,insomnia status[Athens Insomnia Scale(AIS)],comfort level[General Comfort Questionnaire(GCQ)],sleep quality[Pittsburgh Sleep Quality Index(PSQI)],and quality of life were assessed in both groups.Results:Compared to the control group,the observation group experienced faster recovery of clinical symptoms,lower AIS scores at 5 and 10 days post-treatment,higher comfort scores,and better sleep quality.Additionally,the observation group showed significant improvements in daytime function,reduced sleep disturbances,enhanced sleep efficiency,decreased use of sleep medications,shorter sleep latency,extended sleep duration,and improved overall sleep quality(P<0.05).Conclusion:The combination of benzalkonium chloride and nifuratel-nystatin proves highly effective in treating fungal vaginitis,facilitating symptom recovery,alleviating insomnia,and enhancing patient comfort and sleep quality.

关 键 词：苯扎氯铵 硝呋太尔制霉素 霉菌性阴道炎 失眠 匹兹堡睡眠质量指数量表 睡眠效率 

分 类 号：R711.31[医药卫生—妇产科学] R338.63[医药卫生—临床医学]