pH响应型壳聚糖-介孔硅负载药物控释体系的研究  

Study of pH-responsive Chitosan-mesoporous Silica Nanoparticles Loading with Drug for Controlled Drug Release

作　　者：桑广健 左凡娇 邱喜龙[2] 王博瑶[3] Sang Guangjian;Zuo Fanjiao;Qiu Xilong;Wang Boyao(Tianjin Medical University Cancer Institute&Hospital,National Clinical Research Center for Cancer,Tianjin's Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin,300060;School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin,301617;School of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin,301617)

机构地区：[1]天津医科大学肿瘤医院/国家恶性肿瘤临床医学研究中心/天津市恶性肿瘤临床医学研究中心/天津市肿瘤防治重点实验室,天津300060 [2]天津中医药大学中药学院,天津301617 [3]天津中医药大学中医学院,天津301617

出　　处：《当代化工研究》2024年第21期191-193,共3页Modern Chemical Research

摘　　要：目的:采用共价结合的方法制备壳聚糖-介孔二氧化硅纳米材料,并能在pH刺激响应下达到控释罗丹明B(Rhodamine B,RDB)的药物释放体系。方法:采用溶胶-凝胶法制备球形蜂窝状介孔二氧化硅纳米粒子(Mesoporous Silica Nanoparticles,MSN),通过在其表面进行功能化修饰氨基,得到氨基化介孔二氧化硅的MSN-NH_(2),再将壳聚糖共价结合到MSN-NH_(2)表面,制备得到pH响应型壳聚糖-介孔二氧化硅纳米材料(MSN@CCS)。对制备所得样品进行SEM、TEM、FT-IR、XRD及氮气吸附解吸附等手段进行结构表征。最后将RDB负载进MSN@CCS体系,在pH=5.8与pH=7.4两种pH条件下的释放行为进行药物控释研究。结果:SEM、TEM表征结果表明MSN具有良好的介孔结构体,材料分散良好,粒径大小均一,同时表明了CCS成功接枝到MSN表面。FT-IR证明MSN表面成功氨基化。氮气吸附和XRD结果表明合成的MSN为典型的MCM-41型。最后释放研究结果表明MSN@CCS体系在pH=5.8时相对于pH=7.4时使内部RDB释放更快且释放量更多。结论:MSN@CCS体系具有pH响应可控释放功能,可为其他药物分子的可控释放提供实验基础。Objective:Chitosan-mesoporous silica nanomaterials were prepared by covalent binding method,and the controlled release system of Rhodamine B(RDB)could be achieved under pH stimulation.Methods:Mesoporous silica nanoparticles(MSN)were prepared by sol-gel method.The MSN-NH_(2)were obtained by functionalization of amino groups on the surface,then chitosan was covalently bound to the surface of MSN-NH_(2),and pH responsive mesoporous silica nanomaterials(MSN@CCS)were prepared.The samples were characterized by SEM,TEM,FT-IR,XRD and nitrogen adsorption and desorption.Finally,RDB was loaded into MSN@CCS,and the release behavior of RDB was studied under pH=5.8 and pH=7.4.Results:The results of SEM and TEM showed that MSN had good mesoporous structure,good dispersion of materials and uniform particle size.Meanwhile,the results showed that CCS was successfully grafted onto MSN surface.The FT-IR results indicated that the surface of MSN was successfully aminated.Nitrogen adsorption and XRD results demonstrated that the synthesized MSN were typical MCM-41 type.Finally,the release results indicated that the release of RDB was faster and higher in MSN@CCS system at pH=5.8 than at pH=7.4.Conclusion:The MSN@CCS system has a pH-responsive controllable release function,which can provide an experimental basis for the controllable release of other drug molecules.

关 键 词：介孔硅 壳聚糖 pH响应型 药物控释 

分 类 号：R[医药卫生]