中药单体在肿瘤免疫治疗中的作用  

Traditional Chinese medicine monomers in tumor immunotherapy

作　　者：翟锦钰 董智鑫 邬海龙 ZHAI Jinyu;DONG Zhixin;WU Hailong(Graduate School of Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Collaborative Research Center,Shanghai University of Medicine&Health Sciences,Shanghai 201318,China)

机构地区：[1]上海中医药大学研究生院,上海201203 [2]上海健康医学院协同科研中心,上海201318

出　　处：《生命的化学》2024年第11期1981-1989,共9页Chemistry of Life

摘　　要：随着肿瘤免疫治疗不断出现突破性的进展,中药调控免疫系统的机制研究也获得越来越多地受到关注。根据免疫调节特性,中药单体可以通过改善肿瘤微环境免疫状况、靶向相关细胞因子达到抗肿瘤的免疫治疗效果。本文介绍了肿瘤免疫治疗方法,从免疫调控的角度总结了参与促进免疫治疗的中药单体,为探讨中药单体抗肿瘤的作用机制及免疫治疗靶点提供思路。With the continuous breakthrough progress of tumor immunotherapy,the mechanism of traditional Chinese medicine regulating the immune system has also attracted more and more attention.According to the immunomodulatory properties of traditional Chinese medicine monomers,anti-tumor immunotherapy was achieved by improving the immune status of the tumor microenvironment and targeting related cytokines.This review introduces the methods of tumor immunotherapy,and summarizes the traditional Chinese medicine monomers involved in promoting immunotherapy from the perspective of immune regulation,which will provide ideas for exploring the anti-tumor mechanism and immunotherapy targets of traditional Chinese medicine monomers.

关 键 词：肿瘤免疫治疗 中药单体 免疫检查点 免疫细胞 

分 类 号：R730.51[医药卫生—肿瘤]