慢性鼻-鼻窦炎发病机制研究进展  

Research progress of pathogenesis in chronic rhinosinusitis

作　　者：朱子鑫 江黎珠[2] ZHU Zixin;JIANG Lizhu(Chongqing Medical University,Chongqing 400016,China;Department of Otolaryngology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学,重庆400016 [2]重庆医科大学附属第一医院耳鼻咽喉科,重庆400016

出　　处：《生命的化学》2024年第11期2067-2072,共6页Chemistry of Life

摘　　要：慢性鼻-鼻窦炎(chronic rhinosinusitis,CRS)是耳鼻喉科常见疾病,其核心症状表现为流脓鼻涕、鼻塞、嗅觉减退并伴有压迫性头痛和头晕,这些症状严重影响了患者的日常生活和工作,加重了家庭和社会的经济负担。尽管CRS的发病机制尚未完全明确,但已有的研究表明,白细胞介素、表观遗传学和微生物群在CRS病理进展中起到一定作用。本文回顾了近年来白细胞介素、表观遗传学和微生物群在CRS发病过程中的相关研究进展,并提出了三者的相关性可能是CRS发病机制的未来研究方向。Chronic rhinosinusitis(CRS)is a prevalent condition in otolaryngology,characterized by purulent nasal discharge,nasal obstruction,diminished sense of smell,and accompanying pressure headaches and dizziness.These symptoms significantly impair patients’daily lives and work,and exacerbate the economic burden on families and society.Although the pathogenesis of CRS remains unclear,existing research suggests that interleukin,epigenetics,and microbiota may play a role in its pathological progression.This paper reviews the research progress on interleukins,epigenetics,and microbiota in the pathogenesis of CRS,and proposes that the correlation between the three may be a future research direction for the pathogenesis of CRS.

关 键 词：发病机制 慢性鼻-鼻窦炎 微生物群 金黄色葡萄球菌 

分 类 号：R765.41[医药卫生—耳鼻咽喉科]