Mfsd2a跨膜转胞吞功能在中枢神经系统疾病中的作用  

The transmembrane transfer function of major facilitator superfamily domain-containing 2a in the central nervous system disease

作　　者：赵婧钰 张迁 王斌 张敏 王小成 ZHAO Jingyu;ZHANG Qian;WANG Bin;Zhang Min;WANG Xiaocheng(Department of Aviation Medicine,Xijing Hospital,Air Force Medical University,Xi’an 710032,China;Aerospace Clinical Medical Center,School of Aerospace Medicine,Air Force Medical University,Xi’an 710032,China)

机构地区：[1]空军军医大学西京医院空勤科,西安710032 [2]空军军医大学航空航天医学系航空航天临床医学中心,西安710032

出　　处：《生命的化学》2024年第11期2095-2099,共5页Chemistry of Life

基　　金：国家自然科学基金项目(82373610);陕西省科重点研发计划项目(2024SF-YBXM-044)。

摘　　要：血脑屏障(blood-brain barrier,BBB)在中枢神经系统疾病进程中发挥重要作用,主要促因子超家族结构域蛋白2a(major facilitator superfamily domain containing protein 2a,Mfsd2a)影响神经元的形态和突触连接,抑制囊泡转运进而维持正常的血脑屏障结构与功能。本文介绍了Mfsd2a跨膜转运功能在神经系统疾病中的不同作用及相关机制,分析了Mfsd2a可能通过转胞吞作用参与神经系统疾病的发生和发展,旨在为BBB功能障碍所致神经系统疾病提供治疗理论参考。The blood-brain barrier(BBB)has played an important role in the progression of central nervous system(CNS)diseases.Major facilitator superfamily domain containing protein 2a(Mfsd2a)affects the morphology of neurons and synaptic connections,and by inhibiting vesicular transport,it helps maintain the normal structure and function of the BBB.This paper introduces the different roles and related mechanisms of Mfsd2a’s transmembrane transport function in neurological diseases,and analyzes how Mfsd2a may participate in the occurrence and development of neurological diseases through transcytosis.The aim is to provide theoretical references for the treatment of neurological diseases caused by BBB dysfunction.

关 键 词：主要促进因子超家族结构域蛋白2a 血脑屏障 中枢神经系统疾病 

分 类 号：R741.02[医药卫生—神经病学与精神病学]