药物诱导骨肉瘤细胞铁死亡的研究进展  

Research progress of drug-induced ferroptosis in osteosarcoma cells

作　　者：柯义兵 阿布都克热木·达吾提 兰志杰 郭浩然 王勇平[2] KE Yibing;ABUDUKEREMU Dawuti;LAN Zhijie;GUO Haoran;WANG Yongping(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Orthopedics,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院骨科,兰州730000

出　　处：《生命的化学》2024年第11期2119-2126,共8页Chemistry of Life

基　　金：甘肃省高等学校科研项目(2023CYZC-03);兰州市人才创新创业项目(2021-RC-114);兰州大学第一医院科研计划项目(LDYYYN 2021-12)。

摘　　要：骨肉瘤(osteosarcoma,OS)是青少年最常见的骨科原发性恶性骨肿瘤,具有高度侵袭性。近几十年来,化疗药物的发展显著降低了骨肉瘤的复发转移率。但是由于化疗耐药性的产生,OS患者的生存率仍然处于平台期,为此需要寻找新的治疗方式。铁死亡(ferroptosis)是一种新发现的不同于凋亡和自噬的铁依赖性的细胞死亡。研究表明,诱导肿瘤细胞发生的铁死亡已经在乳腺癌、胃癌等多种癌症中发挥积极治疗作用。诱导骨肉瘤细胞铁死亡可能会是抗骨肉瘤的一种新的治疗方式。本文综述了铁死亡的过程以及药物通过诱导骨肉瘤细胞铁死亡发挥抗肿瘤作用的研究进展。Osteosarcoma(OS)is the most common orthopaedic primary malignant bone tumor in adolescents,which is highly invasive.In recent decades,with the development of chemotherapy drugs,the recurrence and metastasis rate of osteosarcoma has been significantly reduced.However,due to the emergence of chemotherapy resistance,the survival rate of patients with OS is still at a plateau,so it is necessary to find a new treatment.Ferroptosis is a newly discovered iron-dependent cell death mechanism which is different from apoptosis and autophagy.Studies have shown that the way of inducing ferroptosis of tumor cells has played an active role in the treatment of breast cancer,stomach cancer and other cancers.Inducing ferroptosis of osteosarcoma cells may be a new treatment against osteosarcoma.This work reviewed the process of ferroptosis and the research progress of antitumor effects of drugs induced iron death in osteosarcoma cells.

关 键 词：骨肉瘤 铁死亡 抗肿瘤作用 

分 类 号：R738.1[医药卫生—肿瘤]