Burden of biliary tract carcinoma in China(1990–2021):Findings from the 2021 Global Burden of Disease Study  

中国胆道系统恶性肿瘤疾病负担:2021全球疾病负担数据研究结果

作　　者：Wei Zhang Yi-Jun Wang Jiang-Mei Liu Xu-Heng Sun Yan Jiang Fang Shen Li-Juan Shen Jing Xiang Jun-Feng Zhang Lin-Hua Yang Wen-Guang Wu Tao Chen Hui Wang Min He Li-Guo Liu Wen-Qi Tao Yong-Zhi Chen Yong-Bing Xiang Mao-Lan Li Mai-Geng Zhou Ying-Bin Liu 张薇;王一钧;刘江美;孙旭恒;江燕;沈芳;沈莉娟;相璟;张军峰;杨林华;吴文广;陈涛;王辉;何敏;刘立果;陶雯琦;陈涌智;项永兵;李茂岚;周脉耕;刘颖斌

机构地区：[1]Department of Epidemiology,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200120,China [2]Department of Biliary-Pancreatic Surgery,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200120,China [3]National Center for Chronic and Noncommunicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100050,China [4]Department of Medical Affairs,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200120,China [5]Department of General Surgery,Jiading Branch,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 201800,China [6]Shanghai Key Laboratory of Systems Regulation and Clinical Translation for Cancer,Shanghai 200127,China [7]State Key Laboratory of Systems Medicine for Cancer,Shanghai Cancer Institute,Shanghai 200127,China [8]Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200120,China

出　　处：《Science Bulletin》2024年第22期3547-3557,共11页科学通报（英文版）

基　　金：supported by the Key Program of Shanghai Science and Technology Commission(YDZX20193100004049);National Natural Science Foundation of China(82273016 and 82303937);Open Project of State Key Laboratory of Oncogenes and Related Genes(KF2120);National Key Project of Research and Development Program of China(2021YFC2500404 and 2021YFC2500405);the University-level Scientific Fund of Shanghai University of Medicine and Health Sciences(SSF-24-1602)。

摘　　要：Biliary tract carcinoma(BTC)is a group of malignant tumors that originate in the digestive system and occurs with a high incidence in China.Few consistent and comparable assessments of BTC disease burden have been conducted at national or subnational levels,and little is known about the demographic,temporal,and geographic patterns of epidemiological characteristics and disease burden of BTC in China.The incidence,mortality,disability-adjusted life-years(DALYs),years of life lost(YLLs)due to premature death and years lived with disability(YLDs)of BTC were comprehensively examined by age,sex,and calendar year in the Chinese population,using the methodological framework and analytical strategies used for the 2021 Global Burden of Disease study.All-age incidence increased from 17,077 to 51,720between 1990 and 2021,and the age-standardized incidence rate rose by 13.62%;all-age deaths increased from 17,251 to 37,833,but the age-standardized mortality rate fell by nearly one-fifth.The DALYs rose by 89.57%while the age-standardized DALY rate fell by 23.24%.Variations of the tendencies in BTC burden were found between sexes and age groups.Data for each provincial region indicate that coastal eastern provincial regions have higher incidence and YLD levels,whereas northern provincial regions have higher mortality,DALY,and YLL levels.The proportions of DALYs attributable to high body mass index(BMI)illustrate the growing attribution obesity has made,and high BMI usually puts more burden on northern provincial regions.These results provide evidence to support precise,targeted,and customed public health strategies aimed at enhancing biliary tract health among the Chinese population.

关 键 词：Biliary tract carcinoma China Global burden of disease study Disability-adjusted life-year Year of life lost due to premature death Year lived with disability 

分 类 号：R735.8[医药卫生—肿瘤]