Blood-derived factors to brain communication in brain diseases  

脑疾病中血源性因子与大脑的联系

作　　者：Jiachen He Yanming Zhang Yansu Guo Jiaqi Guo Xi Chen Shuaili Xu Xiaohan Xu Chuanjie Wu Chengeng Liu Jian Chen Yuchuan Ding Marc Fisher Miaowen Jiang Guiyou Liu Xunming Ji Di Wu 何嘉琛;张艳明;郭艳苏;郭佳琦;陈曦;徐率立;许晓晗;吴川杰;刘辰庚;陈健;丁玉川;Marc Fisher;姜缪文;刘桂友;吉训明;吴迪

机构地区：[1]Department of Neurology and China-America Institute of Neuroscience,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [2]Beijing Institute of Brain Disorders,Capital Medical University,Beijing 100053,China [3]Department of Neurobiology,Heilongjiang Provincial Key Laboratory of Neurobiology,Harbin Medical University,Harbin 150081,China [4]Department of Rehabilitation,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [5]Beijing Geriatric Healthcare Center,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [6]The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China [7]Department of Neurosurgery,Xuanwu Hospital,Beijing Institute of Brain Disorders,Capital Medical University,Beijing 100053,China [8]Department of Neurological Surgery,Wayne State University School of Medicine,Detroit MI 46801,USA [9]Department of Neurology,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston MA 02115,USA [10]Beijing Institute of Brain Disorders,Laboratory of Brain Disorders,Ministry of Science and Technology,Collaborative Innovation Center for Brain Disorders,Capital Medical University,Beijing 100069,China [11]Department of Epidemiology and Biostatistics,School of Public Health,Wannan Medical College,Wuhu 241002,China [12]Brain Hospital,Shengli Oilfield Central Hospital,Dongying 257034,China

出　　处：《Science Bulletin》2024年第22期3618-3632,共15页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(82071466,82371470,82071468,and 82201618);the“Sail Plan”Key Medical Specialty(ZYLX202139);the“Mission”Talent Project of Beijing Municipal Administration of Hospitals(SML20150802);the Beijing Municipal Science and Technology Project(Z181100001918026);the Project for Innovation and Development of Beijing Municipal Geriatric Medical Research Center(11000023T000002036320)。

摘　　要：Brain diseases,mainly including acute brain injuries,neurodegenerative diseases,and mental disorders,have posed a significant threat to human health worldwide.Due to the limited regenerative capability and the existence of the blood–brain barrier,the brain was previously thought to be separated from the rest of the body.Currently,various cross-talks between the central nervous system and peripheral organs have been widely described,including the brain-gut axis,the brain-liver axis,the brain-skeletal muscle axis,and the brain-bone axis.Moreover,several lines of evidence indicate that leveraging systemic biology intervention approaches,including but not limited to lifestyle interventions,exercise,diet,blood administration,and peripheral immune responses,have demonstrated a significant influence on the progress and prognosis of brain diseases.The advancement of innovative proteomic and transcriptomic technologies has enriched our understanding of the nuanced interplay between peripheral organs and brain diseases.An array of novel or previously underappreciated blood-derived factors have been identified to play pivotal roles in mediating these communications.In this review,we provide a comprehensive summary of blood-to-brain communication following brain diseases.Special attention is given to the instrumental role of blood-derived signals,positing them as significant contributors to the complex process of brain diseases.The insights presented here aim to bridge the current knowledge gaps and inspire novel therapeutic strategies for brain diseases.

关 键 词：Brain disease Inter-organ communication Blood-borne factors Systemic biology Lifestyle intervention 

分 类 号：R742[医药卫生—神经病学与精神病学]