依达拉奉右莰醇联合尿激酶静脉溶栓对急性脑梗死合并糖尿病患者血清氧化应激水平的影响  

Effect of edaravone and dexborneol combined with urokinase intravenous thrombolysis on serum oxidative stress level in patients with acute cerebral infarction complicated with diabetes mellitus

作　　者：冯晓伟 赵文波 FENG Xiaowei;ZHAO Wenbo(No.3 Neurology Department,Baoji People's Hospital,Baoji 721000;Encephalopathy Department,Xi'an Buchang Traditional Chinese Medicine Heart Encephalopathy Hospital,Xi'an 710082,China)

机构地区：[1]宝鸡市人民医院神经内三科,陕西宝鸡721000 [2]西安步长中医心脑病医院脑病科,陕西西安710082

出　　处：《临床医学研究与实践》2024年第33期59-62,共4页Clinical Research and Practice

摘　　要：目的探讨依达拉奉右莰醇联合尿激酶静脉溶栓对急性脑梗死(ACI)合并糖尿病患者的效果。方法选取50例ACI合并糖尿病患者,以治疗方案差异将其分为对照组(25例,尿激酶静脉溶栓)和研究组(25例,依达拉奉右莰醇联合尿激酶静脉溶栓)。比较两组的治疗效果。结果研究组的治疗总有效率高于对照组(P<0.05)。治疗后,研究组的超氧化物歧化酶(SOD)水平高于对照组,丙二醛(MDA)、活化白细胞黏附分子(ALCAM)、血小板内皮细胞黏附分子-1(PECAM-1)及簇集蛋白(CLU)水平低于对照组(P<0.05)。治疗后,研究组的脑动脉平均血流速度、舒张期血流速度、收缩期峰值血流速度大于对照组,颈动脉内-中膜厚度(IMT)小于对照组(P<0.05)。治疗后,研究组的N-乙酰天门冬氨酸(NAA)/肌酸(Cr)及胼胝体侧束和下额枕束各向异性分数大于对照组,胆碱复合物(Cho)/Cr小于对照组(P<0.05)。结论依达拉奉右莰醇联合尿激酶静脉溶栓治疗ACI合并糖尿病患者的效果较好。Objective To investigate the effect of edaravone and dextrorphan combined with urokinase intravenous thrombolysis in patients with acute cerebral infarction(ACI)and diabetes mellitus.Methods A total of 50 patients with ACI complicated with diabetes mellitus were selected and divided into control group(25 cases,urokinase intravenous thrombolysis)and study group(25 cases,edaravone and dexborneol combined with urokinase intravenous thrombolysis)according to different treatment schemes.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).After treatment,the level of superoxide dismutase(SOD)in the study group was higher than that in the control group,and the levels of malondialdehyde(MDA),activated leukocyte cell adhesion molecule(ALCAM),plateletendothelial cell adhesion molecule-1(PECAM-1)and clusterin(CLU)were lower than those in the control group(P<0.05).After treatment,the mean blood flow velocity,diastolic blood flow velocity and systolic peak blood flow velocity of cerebral artery in the study group were higher than those in the control group,and the intima-media thickness(IMT)was smaller than that in the control group(P<0.05).After treatment,the N-acetyl aspartic acid(NAA)/creatine(Cr)and the fractional anisotropy of corpus callosum lateral bundle and inferior fronto-occipital bundle in the study group were larger than those in the control group,and choline(Cho)/Cr was smaller than that in the control group(P<0.05).Conclusion Edaravone and dexborneol combined with urokinase intravenous thrombolysis has a good effect in the treatment of ACI patients complicated with diabetes mellitus.

关 键 词：急性脑梗死 糖尿病 依达拉奉右莰醇 尿激酶 静脉溶栓 

分 类 号：R743[医药卫生—神经病学与精神病学]