NOSE完全腹腔镜根治性手术对结直肠癌患者肛门排气时间及住院时间的影响  

Effects of complete laparoscopic radical surgery by NOSE on anal exhaust time and hospital stay in patients with colorectal cancer

作　　者：徐斌 曾庆房 XU Bin;ZENG Qingfang(General Surgery(Hepatobiliary)Department,Xi'an Daxing Hospital,Xi'an 710000,China;Gastrointestinal Surgery Department,Xi'an Daxing Hospital,Xi'an 710000,China)

机构地区：[1]西安大兴医院普外(肝胆)科,陕西西安710000 [2]西安大兴医院胃肠外科,陕西西安710000

出　　处：《临床医学研究与实践》2024年第33期99-102,共4页Clinical Research and Practice

摘　　要：目的分析经自然腔道取出标本(NOSE)完全腹腔镜根治性手术治疗结直肠癌患者的有效性与安全性。方法选取我院2020年1月至2022年12月收治的100例结直肠癌患者为研究对象,随机将其分为常规组(50例,常规腹腔镜结直肠癌根治术治疗)和观察组(50例,NOSE完全腹腔镜根治性手术治疗)。比较两组的手术效果。结果两组的治疗总有效率无显著差异(P>0.05)。两组的手术时间、术中出血量均无显著差异(P>0.05);观察组的肛门排气时间、肠蠕动时间、卧床时间、住院时间均显著短于常规组(P<0.05)。观察组的术后并发症总发生率显著低于常规组(P<0.05)。术前,两组的肿瘤坏死因子-α(TNF-α)、γ干扰素(IFN-γ)、前列腺素E_(2)(PGE_(2))、髓过氧化物酶(MPO)、超敏C反应蛋白(hs-CRP)及白细胞介素-17(IL-17)水平均无显著差异(P>0.05);术后,观察组的TNF-α、IFN-γ、PGE_(2)、MPO、hs-CRP、IL-17水平均显著低于常规组(P<0.05)。结论NOSE完全腹腔镜根治性手术治疗结直肠癌的效果显著,且安全性较高。Objective To analyze the effectiveness and safety of complete laparoscopic radical surgery for colorectal cancer patients by natural orifice specimen extraction(NOSE).Methods A total of 100 patients with colorectal cancer admitted in our hospital from January 2020 to December 2022 were selected as the research objects and randomly divided into conventional group(50 cases,treated with routine laparoscopic radical resection of colorectal cancer)and observation group(50 cases,treated with complete laparoscopic radical surgery by NOSE).The surgical effects of the two groups were compared.Results There was no significant difference in the total effective rate of treatment between the two groups(P>0.05).There were no significant differences in operation time and intraoperative blood loss between the two groups(P>0.05);the anal exhaust time,intestinal peristalsis time,bedridden time and hospital stay of the observation group were significantly shorter than those of the conventional group(P<0.05).The total incidence of postoperative complications in the observation group was significantly lower than that in the conventional group(P<0.05).Before operation,there were no significant differences in the levels of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),prostaglandin(PGE_(2)),myeloperoxidase(MPO),high sensitivity C-reactive protein(hs-CRP)and interleukin-17(IL-17)between the two groups(P>0.05);after operation,the levels of TNF-α,IFN-γ,PGE_(2),MPO,hs-CRP and IL-17 in the observation group were significantly lower than those in the conventional group(P<0.05).Conclusion The complete laparoscopic radical surgery by NOSE in the treatment of colorectal cancer has significant effect and high safety.

关 键 词：结直肠癌 经自然腔道取出标本 完全腹腔镜根治性手术 常规腹腔镜结直肠癌根治术 

分 类 号：R735.3[医药卫生—肿瘤]