Biofabrication and biomanufacturing in Ireland and the UK  

作　　者：Jack F.Murphy Martha Lavelle Lisa Asciak Ross Burdis Hannah J.Levis Cosimo Ligorio Jamie Mc Guire Marlene Polleres Poppy O.Smith Lucinda Tullie Juan Uribe-Gomez Biqiong Chen Jonathan I.Dawson Julien E.Gautrot Nigel M.Hooper Daniel J.Kelly Vivian S.W.Li Alvaro Mata Abhay Pandit James B.Phillips Wenmiao Shu Molly M.Stevens Rachel L.Williams James P.K.Armstrong Yan Yan Shery Huang 

机构地区：[1]Department of Engineering,University of Cambridge,Cambridge CB21PZ,UK [2]Department of Translational Health Sciences,Bristol Medical School,University of Bristol,Bristol BS13NY,UK [3]Department of Biomedical Engineering,University of Strathclyde,Glasgow G40NW,UK [4]Department of Materials,Institute of Biomedical Engineering,Imperial College London,London SW72AZ,UK [5]Department of Bioengineering,Institute of Biomedical Engineering,Imperial College London,London SW72AZ,UK [6]Department of Eye and Vision Science,Institute of Life Course and Medical Sciences,University of Liverpool,Liverpool L78TX,UK [7]Biodiscovery Institute,University of Nottingham,Nottingham NG72RD,UK [8]Department of Chemical and Environmental Engineering,University of Nottingham,Nottingham NG72RD,UK [9]Centre for Human Development,Stem Cells and Regeneration,Human Development and Health,Faculty of Medicine,University of Southampton,Southampton S0166YD,UK [10]Division of Neuroscience,School of Biological Sciences,Faculty of Biology,Medicine and Health,University of Manchester,Manchester M139PT,UK [11]UCL Centre for Nerve Engineering,Department of Pharmacology,UCL School of Pharmacy,University College London,London WC1N 1AX,UK [12]Stem Cell and Cancer Biology Laboratory,The Francis Crick Institute,London NW11AT,UK [13]CÚRAM,SFI Research Centre for Medical Devices,University of Galway,Galway H91 W2TY,Ireland [14]School of Mechanical and Aerospace Engineering,Queen’s University Belfast,Belfast BT95AH,UK [15]School of Engineering and Materials Science,Queen Mary University of London,London E14NS,UK [16]Geoffrey Jefferson Brain Research Centre,Manchester Academic Health Science Centre,Northern Care Alliance and University of Manchester,Manchester M139PL,UK [17]Trinity Centre for Biomedical Engineering,Trinity Biomedical Sciences Institute,Trinity College Dublin,Dublin 2,Ireland [18]Department of Mechanical,Manufacturing and Biomedical Engineering,School of Engineering,Trinity College Dublin,Dublin 2,Ireland [19]Advanced Materials and Bioenginee

出　　处：《Bio-Design and Manufacturing》2024年第6期825-856,共32页生物设计与制造（英文）

基　　金：supported by the W.D.Armstrong Trust.YYSH is funded by the European Research Council(ERC-St G,758865);the UK Research and Innovations(UKRI)Biotechnology and Biological Sciences Research Council(BB/W014564/1);funding from a UKRI Future Leaders Fellowship(MR/V024965/1);supported by the BBSRC London Interdisciplinary Doctoral(LIDo)Programme;the funding support of EPSRC(EP/W004860/1,EP/X033686/1)and MRC(MR/V029827/1,MR/W030381/1);the European Research Council(Pro Li Cell,772462)for support;the NIHR Nottingham Biomedical Research Centre,University of Nottingham,Nottingham,UK and the AO Foundation,AO CMF(AOCMF-21-04S);funding support from grant MR/W01470X/1;the EPSRC(EP/W018977/1)for financial support;funding from the EPSRC(EP/T020792/1);funding from Biomat DB+(Horizon Europe 101058779);funding received from Science Foundation Ireland(SFI)—Grant No.13/RC/2073_P2。

摘　　要：As we navigate the transition from the Fourth to the Fifth Industrial Revolution,the emerging fields of biomanufacturing and biofabrication are transforming life sciences and healthcare.These sectors are benefiting from a synergy of synthetic and engineering biology,sustainable manufacturing,and integrated design principles.Advanced techniques such as 3D bioprinting,tissue engineering,directed assembly,and self-assembly are instrumental in creating biomimetic scaffolds,tissues,organoids,medical devices,and biohybrid systems.The field of biofabrication in the United Kingdom and Ireland is emerging as a pivotal force in bioscience and healthcare,propelled by cutting-edge research and development.Concentrating on the production of biologically functional products for use in drug delivery,in vitro models,and tissue engineering,research institutions across these regions are dedicated to innovating healthcare solutions that adhere to ethical standards while prioritising sustainability,affordability,and healthcare system benefits.

关 键 词：BIOPRINTING Drug delivery BIOMATERIALS Tissue engineering SUSTAINABILITY Biohybrid 

分 类 号：R318[医药卫生—生物医学工程]