Recent biological applications of corroles:From diagnosis to therapy  

咔咯在生物医学领域的应用研究:从诊断到治疗

作　　者：XU Jialiang CUI Jiabin 徐嘉梁;崔家斌(苏州大学放射医学与辐射防护国家重点实验室,放射医学与防护学院,江苏高校放射医学协同创新中心,苏州215123)

机构地区：[1]State Key Laboratory of Radiation Medicine and Protection,School of Radiation Medicine and Protection,Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou,Jiangsu 215123,China

出　　处：《无机化学学报》2024年第12期2303-2317,共15页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金青年项目(No.22104105);江苏省自然科学基金青年项目(No.bk20210702);姑苏创新创业青年领军人才项目(No.zxl2022515)资助。

摘　　要：Corrole,a representative branch of porphyrin,has recently gained popularity.These molecules,viewed as ring‑contracted porphyrinoids containing direct pyrrole‑pyrrole linkages due to the absence of a meso‑carbon atom,exhibit significant photo‑physicochemical properties that make them attractive for various applications.Herein,this review comprehensively discusses the remarkable properties of corrole complexes,as well as related structures and chelation properties.It further explores the biological applications of corrole complexes for in vivo imaging and anticancer therapy.Additionally,it addresses common research bottlenecks and challenges,providing insights into future potential applications in disease diagnosis and treatment.Generally,this review aims to illuminate the significance of corrole complexes and their promising biological applications.咔咯作为卟啉类化合物的一个代表性分支,近年来受到了科学工作者们越来越多的关注。咔咯分子可以看成是缺少了1个中位碳原子而使得吡咯环直接相连的缩环卟啉,因而表现出优异的光物理化学性质,使其在多种应用领域更具吸引力。本文全面讨论了咔咯及其配合物的独特性质以及相关结构和金属配位螯合特性,系统地探讨了咔咯配合物在活体成像、癌症治疗中的生物学应用,归纳总结了目前咔咯配合物研究的瓶颈和挑战,以及咔咯配合物在未来疾病诊断和治疗中的潜在应用。总的来说,这篇综述旨在阐明咔咯配合物研究的重要性,并推动相关领域的进一步发展。

关 键 词：CORROLE metallocorrole photodynamic therapy in vivo imaging THERANOSTIC 

分 类 号：O641.4[理学—物理化学]