磷酸烯醇式丙酮酸羧激酶-1在恶性肿瘤中的研究进展  

Research progress of phosphoenolpyruvate carboxykinase-1 in malignant tumors

作　　者：严华悦 刘子祥 周少波 Yan Huayue;Liu Zixiang;Zhou Shaobo(Department of General Surgery,Bengbu Hospital of Shanghai General Hospital(the Second Affiliated Hospital of Bengbu Medical University),Bengbu 233000,China)

机构地区：[1]上海市第一人民医院蚌埠医院(蚌埠医科大学第二附属医院)普外科,233000

出　　处：《中华普通外科学文献（电子版）》2024年第6期452-456,共5页Chinese Archives of General Surgery(Electronic Edition)

基　　金：安徽省高等学校自然科学研究重点项目(2022AH051476);蚌埠医学院自然科学重点项目(2021byzd197);蚌埠医学院2023年度研究生科研创新计划项目(Byycx23125)。

摘　　要：磷酸烯醇式丙酮酸羧激酶-1(PCK1)是生物体内糖异生途径的关键酶之一。近年来研究证实,PCK1在消化道肿瘤、肾透明细胞癌、乳腺癌、黑色素瘤等多种肿瘤发生、发展中发挥关键调控作用。本文在PCK1概述的基础上,重点阐述PCK1在肿瘤中的差异表达、信号转导、生理过程及调节肿瘤药物治疗敏感性的独特作用,旨在为临床开发抗癌药物提供新的思路。Phosphoenolpyruvate carboxykinase-1(PCK1)is one of the key enzymes in the gluconeogenesis pathway in vivo.In recent years,studies have confirmed that PCK1 plays a key regulatory role in the occurrence and development of various tumors such as gastrointestinal tumors,renal clear cell carcinoma,breast cancer,and melanoma.Based on the overview of PCK1,this article focuses on the unique role of PCK1 in tumor differential expression,signal transduction,physiological processes,and regulation of tumor drug sensitivity,aiming to provide new ideas for clinical development of anticancer drugs.

关 键 词：磷酸烯醇式丙酮酸羧激酶-1 恶性肿瘤 信号转导 生理过程 药物治疗 作用机制 

分 类 号：R73[医药卫生—肿瘤]